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SML2816

Sigma-Aldrich

BS46 bromide

≥98% (HPLC)

Synonym(s):
(1R,2R,4S,5S,7S)-7-[({4-Fluoro-2-(thiophen-2-yl)phenyl}carbamoyl)oxy]-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium bromide
Empirical Formula (Hill Notation):
C20H22BrFN2O3S
Molecular Weight:
469.37

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

FC1=CC=C(NC(O[C@@H]2C[C@H]([C@@H]3[C@H]4O3)[N+](C)(C)[C@H]4C2)=O)C(C5=CC=CS5)=C1.[Br-]

Biochem/physiol Actions

BS46 is a highly potent and selective muscarinic acetylcholine receptor antagonist that exhibits 33-fold preference for M3R (M3 muscarinic acetylcholine receptor) over M2R. It fully inhibits carbachol-induced inositol monophosphate accumulation as well as ?-arrestin recruitment at M3Rs. BS46 exhibits 100,000-fold selectivity for muscarinic receptors against 21 aminergic and peptidergic GPCRs.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificate of Analysis

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Certificate of Origin

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