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Key Documents

SML2912

Sigma-Aldrich

UNC4976 Trifluoroacetate

≥95% (HPLC)

Synonym(s):

Methyl N6-(bicyclo[2.2.1]heptan-2-yl)-N2-(4-(tert-butyl)benzoyl)-L-phenylalanyl-L-alanyl-L-leucyl-N6-methyl-L-lysyl-L-serinate trifluoroacetate

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About This Item

Empirical Formula (Hill Notation):
C47H70N6O8 · xC2HF3O2
Molecular Weight:
847.09 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

assay

≥95% (HPLC)

form

film

color

white to beige

shipped in

wet ice

Storage temp.

−20°C

Biochem/physiol Actions

UNC4976 is a cell penetrant and potent positive allosteric modulator (PAM) of CBX7 chromodomain of polycomb repressive complex 1 that enhances CBX7 chromodomain affinity for nucleic acids. UNC4976 substantially potentiates the expression of polycomb target genes.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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Kelsey N Lamb et al.
Cell chemical biology, 26(10), 1365-1379 (2019-08-20)
Polycomb-directed repression of gene expression is frequently misregulated in human diseases. A quantitative and target-specific cellular assay was utilized to discover the first potent positive allosteric modulator (PAM) peptidomimetic, UNC4976, of nucleic acid binding by CBX7, a chromodomain methyl-lysine reader

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