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SML2967

Sigma-Aldrich

Gp91ds-tat, scrambled trifluoroacetate

≥95% (HPLC)

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Synonym(s):
Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys-Leu-Arg-Ile-Thr-Arg-Gln-Ser-Arg-NH2 trifluoroacetate, Gp91 ds-tat, scrambled trifluoroacetate, NADPH oxidase 2 docking sequence-tat trifluoroacetate, NOX2 ds-tat, scrambled trifluoroacetate, NOX2ds-tat, scrambled trifluoroacetate, RKKRRQRRR-CLRITRQSR-NH2 trifluoroacetate, scrambled Gp91phox docking sequence-tat trifluoroacetate, scrambled NOX2 docking sequence-tat trifluoroacetate
Empirical Formula (Hill Notation):
C98H190N50O22S · xC2HF3O2
Molecular Weight:
2452.94 (free base basis)

Quality Level

Assay

≥95% (HPLC)

form

film or powder

color

white to off-white

storage temp.

−20°C

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This Item
S9317R3905SML3140
form

film or powder

form

solid

form

lyophilized solid

form

powder

color

white to off-white

color

-

color

white

color

white to beige

storage temp.

−20°C

storage temp.

−20°C

storage temp.

room temp

storage temp.

−20°C

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

Biochem/physiol Actions

Inactive control peptide for the NADPH oxidase inhibitor peptide gp91ds-tat (NOX2ds-tat). The control peptide is composed of a membrane-permeant HIV-1 Tat protein transduction domain sequence (aa49-57) N-terminal to a scrambled sequence of murine gp91phox (NOX2) aa86-94.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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F E Rey et al.
Circulation research, 89(5), 408-414 (2001-09-05)
We previously reported enhanced expression of the p67(phox) and gp91(phox) components of NAD(P)H oxidase in angiotensin (Ang) II-induced hypertension, suggesting de novo assembly in response to Ang II. To examine the direct involvement of NAD(P)H oxidases in Ang II-induced O(2)(-)
Dina Vara et al.
Haematologica, 104(9), 1879-1891 (2019-01-27)
The regulation of platelets by oxidants is critical for vascular health and may explain thrombotic complications in diseases such as diabetes and dementia, but remains poorly understood. Here, we describe a novel technique combining electron paramagnetic resonance spectroscopy and turbidimetry
Boris Sabirzhanov et al.
Brain, behavior, and immunity, 80, 73-87 (2019-02-27)
NADPH oxidase (NOX2) is an enzyme that induces reactive oxygen species (ROS) and serves as a switch between the pro-inflammatory and neurorestorative microglial/macrophage phenotypes; such changes play an important role in neuropathic pain and motor dysfunction. Increased NOX2 expression after

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