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SML2972

Sigma-Aldrich

Cyclopentenyl uracil

≥98% (HPLC)

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Synonym(s):
1-[(1R,4R,5S)-4,5-Dihydroxy-3-(hydroxymethyl)-2-cyclopenten-1-yl]-2,4(1H,3H)-pyrimidinedione, Cyclopentenyluracil, Cyclopentenyluridine, NSC 375574
Empirical Formula (Hill Notation):
C10H12N2O5
CAS Number:
Molecular Weight:
240.21

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C10H12N2O5/c13-4-5-3-6(9(16)8(5)15)12-2-1-7(14)11-10(12)17/h1-3,6,8-9,13,15-16H,4H2,(H,11,14,17)/t6-,8-,9+/m1/s1

InChI key

FCWVOJUKQSHZIV-VDAHYXPESA-N

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This Item
SML1162SML2240SML0376
Cyclopentenyl uracil ≥98% (HPLC)

SML2972

Cyclopentenyl uracil

5-Fluoro-1-propargyl-uracil ≥98% (HPLC)

SML1162

5-Fluoro-1-propargyl-uracil

IU1-47 ≥98% (HPLC)

SML2240

IU1-47

CGS 9895 ≥98% (HPLC)

SML0376

CGS 9895

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 1 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: >2 mg/mL (warmed)

color

white to beige

color

white to beige

color

white to beige

color

light yellow to light brown

Biochem/physiol Actions

Cyclopentenyl uracil is a non-cytotoxic inhibitor of uridine kinase that act as a potent inhibitor of pyrimidine salvage in the intact mouse. Combination of Cyclopentenyl uracil with GSK983 significantly reduces viral infection of dengue serotype 2 (DENV-2) strain 16681 in cultures of the A549 lung carcinoma cell line. Cyclopentenyl uracil in combination with GSK983 enhances therapeutic index of viral RdRp inhibitor R1479.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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R L Cysyk et al.
Biochemical pharmacology, 49(2), 203-207 (1995-01-18)
Cyclopentenyl uracil, a non-cytotoxic inhibitor of uridine kinase, was found to effectively block the salvage of circulating uridine by host and tumor tissues in the intact mouse. Dose-response characteristics of the inhibition were determined. Large doses (1 g/kg) of cyclopentenyl
Qi Liu et al.
Cell chemical biology, 27(6), 668-677 (2020-05-23)
Genome-wide analysis of the mode of action of GSK983, a potent antiviral agent, led to the identification of dihydroorotate dehydrogenase as its target along with the discovery that genetic knockdown of pyrimidine salvage sensitized cells to GSK983. Because GSK983 is an

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