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SML3059

Lacosamide

≥98% (HPLC), sodium channel modulator, powder

Synonym(s):

(2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide, ADD 243037, ADD-243037, ADD243037, Erlosamide, LCM, SPM-927, SPM927

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5 MG

$71.40

25 MG

$288.00

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About This Item

Empirical Formula (Hill Notation):
C13H18N2O3
CAS Number:
175481-36-4
Molecular Weight:
250.29
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

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Product Name

Lacosamide, ≥98% (HPLC)

SMILES string

N([C@H](COC)C(=O)NCc1ccccc1)C(=O)C

InChI

1S/C13H18N2O3/c1-10(16)15-12(9-18-2)13(17)14-8-11-6-4-3-5-7-11/h3-7,12H,8-9H2,1-2H3,(H,14,17)(H,15,16)/t12-/m1/s1

InChI key

VPPJLAIAVCUEMN-GFCCVEGCSA-N

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D 13 to 18° (C=0.5g/100mL, MeOH)

drug control

USDEA Schedule V

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

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This Item
SML3523A0737SML3561
Lacosamide ≥98% (HPLC)

Sigma-Aldrich

SML3059

Lacosamide

Solriamfetol hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML3523

Solriamfetol hydrochloride

N-acetylcysteine amide ≥98% (HPLC)

Sigma-Aldrich

A0737

N-acetylcysteine amide

VCP746 ≥98% (HPLC)

Sigma-Aldrich

SML3561

VCP746

form

powder

form

powder

form

lyophilized powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

drug control

USDEA Schedule V

drug control

USDEA Schedule IV

drug control

-

drug control

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: ≥20 mg/mL, DMSO: >40 mg/mL

solubility

DMSO: 2 mg/mL, clear

Biochem/physiol Actions

Lacosamide is an orally active anticonvulsant that blocks voltage-gated sodium channels (VGSCs) selectively in their inactivated state (IC50 = 16 μM/Nav1.8, 182 μM/Nav1.7, 415 μM/Nav1.3) over resting state by enhancing slow inactivation. In addition to in vivo anticonvulsant activity (ED50 = 4.5 mg/kg in mice via i.p., 3.9 mg/kg in rats via p.o. by maximal electroshock seizure test), lacosamide also shows therapeutic efficacy in various pain models (10-30 mg/kg in rats via i.p.).
Orally active anticonvulsant that blocks voltage-gated sodium channels (VGSCs) selectively in inactivated over resting state by enhancing slow inactivation.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000473454
0000473452
0000473452
0000473454
0000445986

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