SML3062

BSJ-04-122-R

Name: BSJ-04-122-R
Brand: SIGMA
Price: 111 USD
Availability: InStock

≥98% (HPLC)

Synonym(s):

N-(2-((5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)phenyl)propionamide

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₄ClN₅O

CAS Number:

2513289-75-1

Molecular Weight:

315.76

UNSPSC Code:

12352200

NACRES:

NA.77

Key Documents

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

ClC1=CNC2=NC=NC(NC3=CC=CC=C3NC(CC)=O)=C21

InChI

1S/C15H14ClN5O/c1-2-12(22)20-10-5-3-4-6-11(10)21-15-13-9(16)7-17-14(13)18-8-19-15/h3-8H,2H2,1H3,(H,20,22)(H2,17,18,19,21)

InChI key

XWBFUHLMYSMDTN-UHFFFAOYSA-N

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This Item	SML3061	SML3475	SML2739
Sigma-Aldrich SML3062 BSJ-04-122-R	Sigma-Aldrich SML3061 BSJ-04-122	Sigma-Aldrich SML3475 PF-04965842	Sigma-Aldrich SML2739 SM1-71-R
assay ≥98% (HPLC)	assay >97% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 2 mg/mL, clear	solubility DMSO: 2 mg/mL, clear	solubility DMSO: 2 mg/mL, clear	solubility DMSO: 2 mg/mL, clear
color white to beige	color white to beige	color white to beige	color white to beige

Biochem/physiol Actions

BSJ-04-122-R is a reversible control for a potent and selective covalent inhibitor of MKK4 and MKK7 BSJ-04-122. BSJ-04-122-R des not inhibit JNK phosphorylation.

reversible control for a potent and selective covalent inhibitor of MKK4 and MKK7 BSJ-04-122

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Discovery of Covalent MKK4/7 Dual Inhibitor.

Jie Jiang et al.

Cell chemical biology, 27(12), 1553-1560 (2020-09-12)

MKK4/7 are kinases that phosphorylate JNKs and regulate the MAPK signaling pathway. Their overexpression has been associated with tumorigenesis and aggressiveness in cancers such as breast, prostate, non-small cell lung, and pediatric leukemia, making them a potential target for inhibitor

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BSJ-04-122-R