All Photos(1)
Synonym(s):
5-Methyl-3,4,14-triazapentacyclo[12.2.2.14,7.02,13.011,19]nonadeca-2,7(19),8,10-tetraene hydrochloride, 5-Methyl-5,8,9,10,11a,12-hexahydro-4H-8,11-ethanopyrido[3′,2′:3,4]diazepino[6,7,1-hi]indole hydrochloride, PSEM 308 hydrochloride, PSEM308 hydrochloride, Pharmacologically selective effector molecule 308, hydrochloride
Empirical Formula (Hill Notation):
C17H21N3 · HCl
Recommended Products
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
CC1CC2=CC=CC3=C2N1N=C(C4CCN5CC4)C5C3.Cl
Biochem/physiol Actions
SEM308 is a pharmacologically selective effector molecule (PSEM) that acts as a selective agonist in vitro and in vivo for chimeric pharmacologically selective actuator modules (PSAMs) composed of nAChR α7 ligand-binding domain (LBD) with L141F or L141F/Y115F mutation fused to the ion pore domain (IPD) of a ligand-gated ion channel (LGIC), including glycine receptor (PSAML141F-GlyR & PSAML141F/Y115F-GlyR) and 5-HT3 (PSAML141F/Y115F-5-HT3).
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Kajana Satkunendrarajah et al.
Nature, 562(7727), 419-422 (2018-10-12)
Dysfunctional breathing is the main cause of morbidity and mortality after traumatic injury of the cervical spinal cord1,2 and often necessitates assisted ventilation, thus stressing the need to develop strategies to restore breathing. Cervical interneurons that form synapses on phrenic
Maria Soledad Esposito et al.
Nature, 508(7496), 351-356 (2014-02-04)
Translating the behavioural output of the nervous system into movement involves interaction between brain and spinal cord. The brainstem provides an essential bridge between the two structures, but circuit-level organization and function of this intermediary system remain poorly understood. Here
Akila Chandrasekar et al.
Cerebral cortex (New York, N.Y. : 1991), 29(6), 2701-2715 (2018-07-10)
Excessive excitation has been hypothesized to subsume a significant part of the acute damage occurring after traumatic brain injury (TBI). However, reduced neuronal excitability, loss of neuronal firing, and a disturbed excitation/inhibition balance have been detected. Parvalbumin (PV) interneurons are
Jayeeta Basu et al.
Neuron, 79(6), 1208-1221 (2013-09-21)
How does coordinated activity between distinct brain regions implement a set of learning rules to sculpt information processing in a given neural circuit? Using interneuron cell-type-specific optical activation and pharmacogenetic silencing in vitro, we show that temporally precise pairing of
Daisuke Satoh et al.
Neuron, 89(5), 1046-1058 (2016-03-01)
The most commonly used locomotor strategy in rodents is left-right limb alternation. Mutation of the axon guidance molecule EphA4 profoundly alters this basic locomotor pattern to synchrony. Here we report that conditional mutation of EphA4 in spinal interneurons expressing the
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