MilliporeSigma
All Photos(1)

SML3105

Sigma-Aldrich

K-7174 dihydrochloride

≥98% (HPLC)

Synonym(s):
1,4-bis((E)-5-(3,4,5-Trimethoxyphenyl)pent-4-enyl)-1,4-diazepane dihydrochloride, K 7174 dihydrochloride, K7174 dihydrochloride, N,N?-bis-(E)-[5-(3,4,5-Trimethoxyphenyl)-4-pentenyl]homopiperazine dihydrochloride
Empirical Formula (Hill Notation):
C33H48N2O6 · 2HCl
CAS Number:
Molecular Weight:
641.67
MDL number:

Quality Level

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

COC(C(OC)=C1)=C(C=C1/C=C/CCCN(CCC2)CCN2CCC/C=C/C3=CC(OC)=C(C(OC)=C3)OC)OC.[H]Cl.[H]Cl

Biochem/physiol Actions

K-7174 is a homopiperazine with dual GATA and proteasome inhibitory activtiy. K-7174 selective inhibts GATA-mediated gene regulations in cultures (10-30 μM; VCAM-1 expression in HUVECs or Epo suppression in Hep3B cells) and in vivo (30 mg/kg in mice via i.p. against IL-1beta- or TNF-alpha-induced anemia). K-7174 exhibits anti-myeloma activity in vitro (10-25 μM) and in vivo (50 mg/kg/day p.o. in mice) by targeting the active pockets of β1, β2 and β5 subunits of proteasome along hydrophobic grooves in the direction of the β7, β1 and β4 subunits in a manner distinct from that of bortezomib.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More Documents

SDS

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service