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SML3162

A-1155463

≥98% (HPLC)

Synonym(s):

2-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-4-thiazolecarboxylic acid, A 1155463

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$136.00

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About This Item

Empirical Formula (Hill Notation):
C35H32FN5O4S2
CAS Number:
1235034-55-5
Molecular Weight:
669.79
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD29924714
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

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InChI

1S/C35H32FN5O4S2/c1-40(2)17-6-8-22-14-15-28(26(36)20-22)45-19-7-13-30-31(33(43)44)38-35(47-30)41-18-16-23-9-5-10-24(25(23)21-41)32(42)39-34-37-27-11-3-4-12-29(27)46-34/h3-5,9-12,14-15,20H,7,13,16-19,21H2,1-2H3,(H,43,44)(H,37,39,42)

InChI key

SOYCFODXNRVBTI-UHFFFAOYSA-N

SMILES string

O=C(C1=C(CN(C2=NC(C(O)=O)=C(CCCOC3=CC=C(C#CCN(C)C)C=C3F)S2)CC4)C4=CC=C1)NC5=NC6=C(S5)C=CC=C6

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

Quality Level

100

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Show Differences

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SML1932SML3176SML3181
A-1155463 ≥98% (HPLC)

Sigma-Aldrich

SML3162

A-1155463

A-1210477 ≥98% (HPLC)

Sigma-Aldrich

SML1932

A-1210477

WEHI-539 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML3176

WEHI-539 hydrochloride

7,8-Dimethoxyperphenazine ≥98% (HPLC)

Sigma-Aldrich

SML3181

7,8-Dimethoxyperphenazine

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

faint yellow to dark orange

color

white to beige

Biochem/physiol Actions

highly potent and selective BCL-XL inhibitor
A-1155643 is a highly potent and highly selective BCLXL inhibitor that inhibits H146 small cell lung cancer xenograft tumor growth in mice.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000137088
0000137089

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G Brent Dawe et al.
Nature communications, 10(1), 2746-2746 (2019-06-23)
Nicotinic acetylcholine receptors (nAChRs) mediate and modulate synaptic transmission throughout the brain, and contribute to learning, memory, and behavior. Dysregulation of α7-type nAChRs in neuropsychiatric as well as immunological and oncological diseases makes them attractive targets for pharmaceutical development. Recently
Zhi-Fu Tao et al.
ACS medicinal chemistry letters, 5(10), 1088-1093 (2014-10-15)
A-1155463, a highly potent and selective BCL-XL inhibitor, was discovered through nuclear magnetic resonance (NMR) fragment screening and structure-based design. This compound is substantially more potent against BCL-XL-dependent cell lines relative to our recently reported inhibitor, WEHI-539, while possessing none
Anne Slomp et al.
Blood advances, 3(24), 4202-4214 (2019-12-20)
Prosurvival BCL-2 family proteins are potent inhibitors of apoptosis and often overexpressed in lymphoid malignancies. In multiple myeloma (MM), MCL-1 expression contributes to survival of malignant plasma cells, and overexpression correlates with poor prognosis. In this study, we investigated whether

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