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SML3284

Sigma-Aldrich

MS1943

≥98% (HPLC)

Synonym(s):

N-​[(1,​2-​Dihydro-​4,​6-​dimethyl-​2-​oxo-​3-​pyridinyl)​methyl]​-​1-​(1-​methylethyl)​-​6-​[6-​[4-​[2-​[(2-​tricyclo[3.3.1.13,​7]​dec-​1-​ylacetyl)​amino]​ethyl]​-​1-​piperazinyl]​-​3-​pyridinyl]​-1H-​indazole-​4-​carboxamide

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About This Item

Empirical Formula (Hill Notation):
C42H54N8O3
CAS Number:
Molecular Weight:
718.93
UNSPSC Code:
12352200
NACRES:
NA.77

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Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

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1 of 4

This Item
SML3664SML3439SML3328
form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

-10 to -25°C

storage temp.

−20°C

storage temp.

-10 to -25°C

solubility

DMSO: 2 mg/mL, clear (Warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

Biochem/physiol Actions

MS1943 is a potent and selective degrader of EZH2 (enhancer of zeste homolog 2) that effectively reduces EZH2 levels in cells. MS1943 potently inhibits growth of multiple TNBC cells and in mice xenograft model.
Potent and selective degrader of EZH2 (enhancer of zeste homolog 2) that effectively reduces EZH2 levels in cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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