SML3341
ML-SA5
≥98% (HPLC)
Synonym(s):
N1-(3-Chloro-2-(piperidin-1-yl)phenyl)-N4,N4-dimethylbenzene-1,4-disulfonamide
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About This Item
Empirical Formula (Hill Notation):
C19H24ClN3O4S2
CAS Number:
Molecular Weight:
457.99
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
1 of 4
This Item | SML2073 | SML3007 | SML1505 |
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
| storage condition desiccated | storage condition desiccated | storage condition - | storage condition - |
| solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 5 mg/mL, clear (warmed) |
| Quality Level 100 | Quality Level - | Quality Level 100 | Quality Level 100 |
Biochem/physiol Actions
ML-SA5 is a potent TRPML cation channel agonist that activates whole-endolysosomal TRPML1 (ML1) currents in DMD myoblasts at a higher potency than ML-SA1 (EC50 = 285 nM vs 10 μM). ML-SA5 ameliorates muscular dystrophy in mdx, but not ML1-knockout, mice in vivo (2 or 5 mg/kg/day i.p.) by facilitating sarcolemma repair, thereby reducing skeletal and cardiac muscle damage with no apparent toxicity to the animals.
Potent TRPML1 cation channel agonist that ameliorates muscular dystrophy in mdx, but not ML1-KO, mice and with a higher potency than ML-SA1.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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