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  • SML3385
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SML3385

Sigma-Aldrich

Binimetinib

≥98% (HPLC)

Synonym(s):
5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, ARRY 162, ARRY 438162, ARRY-162, ARRY-438162, ARRY162, ARRY438162, MEK 162, MEK-162, MEK162
Empirical Formula (Hill Notation):
C17H15BrF2N4O3
CAS Number:
Molecular Weight:
441.23
MDL number:

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C1=C(C(F)=C(C2=C1)N=CN2C)NC3=C(C=C(C=C3)Br)F)NOCCO

InChI

1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

InChI key

ACWZRVQXLIRSDF-UHFFFAOYSA-N

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Binimetinib ≥98% (HPLC)

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Sigma-Aldrich

SML3012

Dovitinib

assay

≥98% (HPLC)

assay

-

assay

-

assay

≥98% (HPLC)

form

powder

form

-

form

-

form

powder

color

white to beige

color

-

color

-

color

white to beige

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

-

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

100

Quality Level

300

Quality Level

100

Biochem/physiol Actions

Binimetinib (MEK162, ARRY-162) is an orally active, potent, ATP-uncompetitive MEK1/2 inhibitor (IC50 = 12 nM) that inhibits multiple human tumor growth in xenograft mice in vivo regardless of Kras or Braf mutation (30 or 100 mg/kg/day, 100 mg/kg b.i.d.).

Pictograms

Environment

Hazard Statements

Precautionary Statements

Hazard Classifications

Aquatic Chronic 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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