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SML3602

Sigma-Aldrich

Pipobroman

≥98% (HPLC)

Synonym(s):

1,​1′-​(1,​4-​Piperazinediyl)​bis[3-​bromo-1-​propanone, 1,​4-​bis(3-​Bromo-​1-​oxopropyl)​-piperazine, N,N-Bis-(3-bromopropionyl)-piperazine, NSC-​25154

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About This Item

Empirical Formula (Hill Notation):
C10H16Br2N2O2
CAS Number:
54-91-1
Molecular Weight:
356.05
MDL number:
MFCD00866372
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

BrCCC(=O)N1CCN(CC1)C(=O)CCBr

InChI

1S/C10H16Br2N2O2/c11-3-1-9(15)13-5-7-14(8-6-13)10(16)2-4-12/h1-8H2

InChI key

NJBFOOCLYDNZJN-UHFFFAOYSA-N

Biochem/physiol Actions

Anti-cancer drug, cytostatic alkylating agent
Pipobroman is an alkylating agent that is used as anti-cancer drug. It also has clinical activity in polycythemia vera and thrombocythemia.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000230089
0000230088

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Giovanni Fazio et al.
Journal of thrombosis and thrombolysis, 35(2), 282-285 (2012-07-31)
Polycythemia vera (PV) is a chronic myeloproliferative disorder characterized by an abnormal increase in red blood cells. The involvement of the heart during the course of the illness represents a common cause of morbidity and it is linked to an
Jean-Jacques Kiladjian et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29(29), 3907-3913 (2011-09-14)
The overall impact of hydroxyurea (HU) or pipobroman treatments on the long-term outcome of patients with polycythemia vera (PV) has not been assessed in randomized studies. We report final analyses from the French Polycythemia Study Group (FPSG) study, which randomly

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