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SML3722

Sigma-Aldrich

Dinaciclib

≥98% (HPLC)

Synonym(s):

(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol, 2-[(2S)-1-[3-Ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol, MK 7965, MK-7965, MK7965, SCH 727965, SCH-727965, SCH727965

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About This Item

Empirical Formula (Hill Notation):
C21H28N6O2
CAS Number:
Molecular Weight:
396.49
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.21

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Quality Level

assay

≥98% (HPLC)

form

powder

color

, White to light brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

[n+]1(cc(ccc1)CNC2=CC(=Nc4[n]2ncc4CC)N3[C@@H](CCCC3)CCO)[O-]

InChI key

PIMQWRZWLQKKBJ-SFHVURJKSA-N

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Show Differences

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This Item
SML3480SML3428SML2871
ULK-101 ≥98% (HPLC)

SML3480

ULK-101

GLPG2938 ≥97% (HPLC)

SML3428

GLPG2938

Udenafil ≥98% (HPLC)

SML2871

Udenafil

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

-10 to -25°C

storage temp.

-10 to -25°C

storage temp.

-10 to -25°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

, White to light brown

color

white to beige

color

white to beige

color

white to beige

Biochem/physiol Actions

Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor (CDK1/2/5/6/7/9 IC50 = 3/1/1/12/7/4 nM; Little or no inhibition of 41 other kinases at 10 μM) with potent antiproliferation activity in A2780 ovarian cancer cultures (IC50 = 4 nM by thymidine uptake assays). Dinaciclib exhibits potent anti-cancer efficacy in cultures (IC50 = 6-17 nM against 14 cancer cell lines) and in an A2780 tumor xenograft model in mice in vivo (8-48 mg/kg via daily i.p.).
Potent and selective cyclin-dependent kinase (CDK) inhibitor with potent anti-cancer efficacy in cultures and in mice in vivo.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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