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MilliporeSigma

SML3751

Sigma-Aldrich

HS-84

≥98% (HPLC)

Synonym(s):

5,5′′′′-dicarboxy-[2,2′:5′,2′′:5′′,2′′′:5′′′,2′′′′-Quinquethiophene]-3′,4′′′-diacetic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):
C26H12Na4O8S5
CAS Number:
Molecular Weight:
704.65
UNSPSC Code:
12352200
NACRES:
NA.21

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Quality Level

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

, Light orange to very dark red

solubility

H2O: 2 mg/mL, clear

storage temp.

room temp

Biochem/physiol Actions

Brain blood barrier penetrant luminescent probe that binds to binds to fibrillary tau protein
HS-84, a luminescent conjugated oligothiophene, is a brain blood barrier penetrant luminescent probe that binds to binds to fibrillary tau protein. HS-84 single photon excitation maximum is ~ 430 nm, and emission maximum are ~ 512, 547 nm. It does not fade within hours. HS-84 is a suitable probe for longitudinal in vivo detection of neurofibrillary tangles using multiphoton microscopy in the Tg mouse brain.

Caution

Hygroscopic

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Questions

  1. We recently purchased HS-84 for in vivo imaging. Literature suggests diluting in PBS to 5 mg/mL for storage, but it's unclear how long and under what conditions it remains stable after dilution. Could you clarify this? Thank you!

    1 answer
    1. We have no internal studies on solution stability and storage with PBS.  We make fresh aliquots each time and recommend this to customers.  One could compare a fresh aliquot to one that has been stored to see if there is a qualitative difference.  

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