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SRE0013

Sigma-Aldrich

Interferon Alpha 2A human

recombinant, expressed in HEK 293 cells, ≥98% (SDS-PAGE), lyophilized powder

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Synonym(s):
Interferon α 2A human, INFα2A

recombinant

expressed in HEK 293 cells

Quality Level

200

Assay

≥98% (SDS-PAGE)

form

lyophilized powder

storage temp.

−20°C

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This Item
I17001H6041H6166
Interferon Alpha 2A human recombinant, expressed in HEK 293 cells, ≥98% (SDS-PAGE), lyophilized powder

Sigma-Aldrich

SRE0013

Interferon Alpha 2A human

Interferon-γ human IFN-gamma, recombinant, expressed in HEK 293 cells, suitable for cell culture, endotoxin tested

Sigma-Aldrich

I17001

Interferon-γ human

Sigma-Aldrich

Sigma-Aldrich

H6041

Interferon α 2A human

Sigma-Aldrich

Sigma-Aldrich

H6166

Interferon α 2B human

assay

≥98% (SDS-PAGE)

assay

≥98% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

100

General description

IFN-α-2a belongs to the type I interferon protein family. Interferon α 2A is one among the three variants of IFN-α2. Recombinant human IFN-α-2a is expressed in human 293 cells as a glycosylated monomer of 165 amino acids, with an average molecular weight of 20 kDa (monomer).

Application

Interferon α 2A human has been used as an inhibitor of hepatitis D virus (HDV).

Biochem/physiol Actions

Interferon Alpha 2A human is produced by many cell types in response to viral infection. IFN-α-2A has antiproliferative and antitumor activities, as well as induction of apoptosis and inflammatory response
Interferon α 2A might be implicated in the regression of proliferative diabetic retinopathy. Telaprevir and pegylated interferon–α-2a (PEG-IFN–α-2a) serves as a potential therapeutic method for hepatitis C virus (HCV). IFN α 2A along with IFN α 2b and IFN α2c exhibits anti-proliferative effect.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Guillaume Beauclair et al.
Journal of virology, 94(22) (2020-09-04)
Yellow fever virus (YFV) is an RNA virus primarily targeting the liver. Severe YF cases are responsible for hemorrhagic fever, plausibly precipitated by excessive proinflammatory cytokine response. Pathogen recognition receptors (PRRs), such as the cytoplasmic retinoic acid inducible gene I
Telaprevir and pegylated interferon?alpha?2a inhibit wild?type and resistant genotype 1 hepatitis C virus replication in patients
Kieffer T L, et al.
Hepatology, 46(3), 631-639 (2007)
Interferon alpha-2a for proliferative diabetic retinopathy after complete laser panretinal photocoagulation treatment.
Leibovitch I, et al.
Ophthalmic Surgery, Lasers & Imaging Retina, 35(1), 16-22 (2004)
Antitumor activities of interferon alpha, beta, and gamma and their combinations on human melanoma cells in vitro: changes of proliferation, melanin synthesis, and immunophenotype
Garbe C, et al.
The Journal of Investigative Dermatology, 95-95 (1990)
Antitumor activities of interferon alpha, beta, and gamma and their combinations on human melanoma cells in vitro: changes of proliferation, melanin synthesis, and immunophenotype.
Garbe C, et al.
The Journal of Investigative Dermatology, 95(6), 231S-237S (1990)
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