Granzyme B human recombinant, expressed in insect cells, Molecular weight is 32kDa as per Uniprot P10144. Please see the link below for more information:
https://www.uniprot.org/uniprot/P10144
SRE0021
Granzyme B human
recombinant, expressed in insect cells, ≥90% (SDS-PAGE)
Synonym(s):
Granzyme B human, Cytotoxic T-lymphocyte proteinase 2, Granzyme-2, GranzymeB, Lymphocyte protease, SECT, T-cell serine protease 1-3E
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| Size/SKU | Availability | Price |
|---|---|---|
5 μg | Usually ships in 2 weeks. | $535.00 |
About This Item
NACRES:
NA.32
UNSPSC Code:
12352204
Specific activity:
≥40 units/μg
Assay:
≥90% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in insect cells
biological source
human
Quality Segment
recombinant
expressed in insect cells
assay
≥90% (SDS-PAGE)
form
lyophilized powder
potency
>0.004 units/mg
specific activity
≥40 units/μg
packaging
pkg of 5 μg
UniProt accession no.
shipped in
wet ice
storage temp.
−70°C
Gene Information
human ... GZMB(3002)
General description
Granzyme B (GzmB) is a serine protease which is stored in granules of activated cytotoxic T cells and NK cells. GZMB codes for granzyme B.
Biochem/physiol Actions
Granzyme B is considered as the marker of activated CTLs (cytotoxic T-cells), which mediates target-cell apoptosis. It induces apoptosis in caspase-dependent and caspase-independent manner. After contact with target cells, granzyme B is directionally exocytosed, and then enters the target cell with assistance from perforin. Granzyme B specifically cleaves after Asp residues, and particularly processes and activates various pro-caspases. This induces apoptosis in the target cell.
Physical form
Lyophilized powder, containing HEPES buffer (original solution at pH 7.5)
Other Notes
One unit is defined as the amount of enzyme that hydrolyzes 1 pmol/min of IETD-AFC per min at 37°C in 50 mM HEPES, pH 7.5 containing 10 mM CaCl2.
1 of 1
This Item | |||
|---|---|---|---|
| Gene Information human ... GZMB(3002) | Gene Information mouse ... GZMB(14939) | Gene Information human ... GZMM(3004) | Gene Information human ... GZMB(3002) |
| biological source human | biological source mouse | biological source mouse | biological source rabbit |
| assay ≥90% (SDS-PAGE) | assay ≥97% (HPLC), ≥97% (SDS-PAGE) | assay - | assay - |
| specific activity ≥40 units/μg | specific activity - | specific activity - | specific activity - |
| recombinant expressed in insect cells | recombinant expressed in Hi-5 Insect cells | recombinant - | recombinant - |
| form lyophilized powder | form lyophilized | form buffered aqueous solution | form buffered aqueous solution |
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Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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What is the molecular weight?
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To whom it may concern, we have recently purchased the granzyme B (SRE0021) and its substrate (SCP0158). Is the enzyme in its active form? What are the best condition for resuspension? Thank you.
1 answer-
The product is provided in active form. It does not require activation. Use 50 µl sterile deionized water to dissolve 5 µg protein to a final concentration of 0.1 µg protein/µl. This solution is stable for 1 year at –70 °C.
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