MilliporeSigma
All Photos(2)

Documents

SRP0349

Sigma-Aldrich

Flt3 active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE)

Sign Into View Organizational & Contract Pricing

Synonym(s):
CD135, FLK2, STK1, fms-related tyrosine kinase 3
CAS Number:
NACRES:
NA.32

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

assay

≥80% (SDS-PAGE)

form

aqueous solution

mol wt

54.2 kDa

packaging

pkg of 10 μg

technique(s)

activity assay: suitable
inhibition assay: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... FLT3(2322)

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
F6432SRP0351SRP0348
Flt3 active human recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE)

SRP0349

Flt3 active human

PDGFRb active human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE)

SRP0351

PDGFRb active human

Sigma-Aldrich

SRP0348

Flt1 active human

biological source

human

biological source

-

biological source

human

biological source

human

technique(s)

activity assay: suitable, inhibition assay: suitable

technique(s)

-

technique(s)

activity assay: suitable, inhibition assay: suitable

technique(s)

activity assay: suitable, inhibition assay: suitable

assay

≥80% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

form

aqueous solution

form

buffered aqueous glycerol solution

form

aqueous solution

form

aqueous solution

mol wt

54.2 kDa

mol wt

~73 kDa

mol wt

62 kDa

mol wt

67.5 kDa

General description

Human Flt3 (GenBank Accession No. NM_004119), amino acids 564-end with N-terminal His-tag, MW=54.2 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Connor P Hall et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 22(3), 621-632 (2015-06-18)
The aim of our study is to evaluate the preclinical therapeutic activity and mechanism of action of BEZ235, a dual PI3K/mTOR inhibitor, in combination with dexamethasone in acute lymphoblastic leukemia (ALL). The cytotoxic effects of BEZ235 and dexamethasone as single
Mark Levis et al.
Blood, 106(2), 673-680 (2005-03-31)
Internal tandem duplication mutations of the FLT3 gene (FLT3/ITD mutations) are the most frequent molecular abnormality in acute myeloid leukemia (AML) and are associated with a poor overall survival. While the normal FLT3 receptor is expressed in early hematopoietic progenitor
Amanda Lance et al.
Leukemia, 34(2), 369-379 (2019-08-30)
Three annotated CSF3R mRNA splice variants have been described. CSF3R-V1 is the wild-type receptor, while CSF3R-V4 is a truncated form increased in some patients with AML. CSF3R-V3 mRNA was identified in placenta more than 20 years ago, but remains largely
Shinichiro Takahashi et al.
Leukemia research, 29(8), 893-899 (2005-06-28)
Activating mutations or over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), associated with activation of Ras/MAP kinase and other signaling pathways. In this study, we addressed the role of Flt3 in the activation of nuclear factor-kappa B
Ophir Shani et al.
Cancer research, 80(23), 5317-5329 (2020-10-08)
Lungs are one of the main sites of breast cancer metastasis. The metastatic microenvironment is essential to facilitate growth of disseminated tumor cells. Cancer-associated fibroblasts (CAF) are prominent players in the microenvironment of breast cancer. However, their role in the

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service