SRP0411
Sestrin 1 human
recombinant, expressed in baculovirus infected Sf9 cells, ≥44% (SDS-PAGE)
Synonym(s):
PA26, SEST1
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50 μG
$722.00
$722.00
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50 μG
$722.00
About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
$722.00
Usually ships in 2 weeks.
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
assay
≥44% (SDS-PAGE)
form
aqueous solution
mol wt
65 kDa
packaging
pkg of 50 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... SESN1(27244)
General description
Human Sestrin1, also known as p53-regulated protein PA26 (GenBank Accession No. NM_014454) full length, amino acids 2-551(end) with N-terminal FLAG-tag, MW=65 kDa, expressed in Sf9 insect cells via a Baculovirus expression system.
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Broderick, G., et al.
The Pharmacogenomics Journal, 7, 407-419 (2006)
Jun Hee Lee et al.
Science (New York, N.Y.), 327(5970), 1223-1228 (2010-03-06)
Sestrins are conserved proteins that accumulate in cells exposed to stress, potentiate adenosine monophosphate-activated protein kinase (AMPK), and inhibit activation of target of rapamycin (TOR). We show that the abundance of Drosophila sestrin (dSesn) is increased upon chronic TOR activation
Andrei V Budanov et al.
Cell, 134(3), 451-460 (2008-08-12)
The tumor suppressor p53 is activated upon genotoxic and oxidative stress and in turn inhibits cell proliferation and growth through induction of specific target genes. Cell growth is positively regulated by mTOR, whose activity is inhibited by the TSC1:TSC2 complex.
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