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SRP0412

Sigma-Aldrich

Sestrin 2 human

recombinant, expressed in baculovirus infected Sf9 cells, ≥35% (SDS-PAGE)

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Synonym(s):
HI95, SES2, SEST2
NACRES:
NA.32

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

Assay

≥35% (SDS-PAGE)

form

aqueous solution

mol wt

55 kDa

packaging

pkg of 50 μg

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... SESN2(83667)

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This Item
APREST72800SAB1405298HPA018191
Sestrin 2 human recombinant, expressed in baculovirus infected Sf9 cells, ≥35% (SDS-PAGE)

Sigma-Aldrich

SRP0412

Sestrin 2 human

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in E. coli

recombinant

-

recombinant

-

assay

≥35% (SDS-PAGE)

assay

>80% (SDS-PAGE)

assay

-

assay

-

form

aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous glycerol solution

mol wt

55 kDa

mol wt

predicted mol wt 31 kDa

mol wt

antigen ~78.91 kDa

mol wt

-

packaging

pkg of 50 μg

packaging

-

packaging

-

packaging

antibody small pack of 25 μL

General description

Sestrin 2 (SESN2), a highly conserved protein, is a member of a family of anti-aging proteins called the sestrins. Human SESN2 (hSESN2) contains three subdomains, such as SESN-A, SESN-B, and SESN-C. The SESN2 gene is mapped to human chromosome 1p35.3.

Application

Sestrin 2 human may be used to study its role on blood brain- barrier (BBB) stabilization after moderate and severe hypoxic- ischemic (HI) injuries in neonatal rats.

Biochem/physiol Actions

Sestrin 2 (SESN2) plays a vital role in modulating cellular stress response and oxidant defense. It plays a regulatory role in energy metabolism, cell fate, liver diseases, inflammation, and carcinogenesis. This novel anti-aging protein aids to maintain mitochondrial activities and enhance mitochondrial health. Since SESN2 is capable of protecting tissues from oxidative stress and mitochondrial dysfunction caused by ischemia or reperfusion (I/R), it may be a promising therapeutic target in hepatic regeneration.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Dongdong Wu et al.
Life sciences, 267, 118941-118941 (2020-12-29)
Acute lung injury (ALI) / acute respiratory distress syndrome (ARDS) is a critical clinical syndrome with complex pathology and pathogenesis. Since there is no specific treatment for ALI, it is important to study the mechanism of how ALI develop. Sestrin2
Xudan Shi et al.
Neurobiology of disease, 95, 111-121 (2016-07-19)
Hypoxic ischemic (HI) encephalopathy remains the leading cause of perinatal brain injury resulting in long term disabilities. Stabilization of blood brain barrier (BBB) after HI is an important target, therefore, in this study we aim to determine the role of
Li-Xue Wang et al.
Frontiers in immunology, 10, 2797-2797 (2019-12-24)
Sestrin2 (SESN2), a highly evolutionarily conserved protein, is critically involved in cellular responses to various stresses. SESN2 has a protective effect on physiological and pathological states mainly via regulating oxidative stress, endoplasmic reticulum stress, autophagy, metabolism, and inflammation. In recent
Raúl P Oliveira et al.
Free radical biology & medicine, 163, 255-267 (2020-12-29)
Liver regeneration is a remarkably complex phenomenon conserved across all vertebrates, enabling the restoration of lost liver mass in a matter of days. Unfortunately, extensive damage to the liver may compromise this process, often leading to the death of affected
Broderick, G., et al.
The Pharmacogenomics Journal, 7, 407-419 (2006)

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