SRP2042

LXRα-ligand binding domain (215-667) human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

• Synonym(s): LXR-a, LXRA, RLD-1
• UNSPSC Code: 12352200
• NACRES: NA.26

Properties

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥70% (SDS-PAGE)
• form: frozen liquid
• mol wt: ~30.6 kDa
• packaging: pkg of 10 μg
• concentration: 300 μg/mL
• color: clear colorless
• NCBI accession no.: NM_005693
• UniProt accession no.: Q13133
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... NR1H3(10062)

Description

Biochem/physiol Actions

Liver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids. There are two subtypes of LXRs, LXR α and LXR β. LXRa is preferentially expressed in liver, small intestine, kidney and spleen. In contrast, LXR β expression is ubiquitous. The genomic structure and the promoter regions of the two LXR genes contain specific regulatory sites, which suggest that LXRs may have physiological roles in the immune system. Like other nuclear receptors, LXRs heterodimerize with retinoid X receptor (RXR) for function. LXRs are activated by naturally occurring oxysterols and regulate the expression of target genes, including ATP binding cassette transporter 1 (ABC1), ATP binding cassette transporter 8 (ABC8) and cholesterol ester transfer protein (CETP). The ligand binding domain (LBD) of LXR determines ligand specificity and mediates the trans-activation function of the receptor.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable