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SRP2045

Sigma-Aldrich

PPAR, γ human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

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Synonym(s):
CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma
NACRES:
NA.26

biological source

human

recombinant

expressed in E. coli

Assay

≥70% (SDS-PAGE)

form

frozen liquid

mol wt

~60 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

500 μg/mL

technique(s)

ligand binding assay: suitable

color

clear colorless

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PPARG(5468)

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PPAR, γ human recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

Sigma-Aldrich

SRP2045

PPAR, γ human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

assay

≥70% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

form

frozen liquid

form

frozen liquid

form

frozen liquid

form

frozen liquid

mol wt

~60 kDa

mol wt

~57.8 kDa

mol wt

~78.7 kDa

mol wt

~60.2 kDa

packaging

pkg of 10 μg

packaging

pkg of 10 μg

packaging

pkg of 10 μg

packaging

pkg of 10 μg

Biochem/physiol Actions

There is evidence that a group of closely related nuclear receptors, called peroxisome proliferator-activated receptors (PPARs), may be involved in chronic diseases such as diabetes, obesity, artherosclerosis and cancer. The PPARs were first cloned as the nuclear receptors that mediate the effects of synthetic compounds called peroxisome proliferators on gene transcription. It soon became clear that eicosanoids and fatty acids can also regulate gene transcription through PPARs. They bind a specific element in the promoter region of target genes only as a heterodimer with the receptor for 9-cis retinoic acid, RXR (retinoid X receptor). Binding of the ligand of either receptor can activate the complex, but binding of both ligands simultaneously is more potent. Three PPAR isotypes have been identified: α, β (also called NUC1) and γ. PPAR α is expressed most in brown adipose tissue and liver, then kidney, heart and skeletal muscle. PPAR β is found in many tissues but the highest expression is in the gut, kidney and heart. PPAR γ is mainly expressed in adipose tissue, and to a lesser extent in colon, the immune system and the retina. The target genes of PPAR α are a relatively homogenous group of genes that participate in aspects of lipid catabolism such as fatty acid uptake through membranes, fatty acid binding in cells, fatty acid oxidation (in microsomes, peroxisomes and mitochondria) and lipoprotein assembly and transport.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Ho Sun Jung et al.
Yonsei medical journal, 52(1), 165-172 (2010-12-15)
Imbalances between osteogenic and adipogenic differentiation leads to diseases such as osteoporosis. The aim of our study was to demonstrate the differences in extracellular signal-regulated kinase (ERK) phosphorylation during both adipogenesis and osteogenesis of human bone marrow-derived stem cells (BMSCs).
E D Rosen et al.
Molecular cell, 4(4), 611-617 (1999-11-05)
The process of adipogenesis is known to involve the interplay of several transcription factors. Activation of one of these factors, the nuclear hormone receptor PPAR gamma, is known to promote fat cell differentiation in vitro. Whether PPAR gamma is required
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
B Desvergne et al.
Endocrine reviews, 20(5), 649-688 (1999-10-26)
S Kersten et al.
Nature, 405(6785), 421-424 (2000-06-06)
In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and cancer are responsible for most deaths. These ailments have complex causes involving genetic, environmental and nutritional factors. There is evidence that a group of closely related nuclear receptors, called

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