The buffer used in Product SRP2057, LXR ?-ligand binding domain (211-461) human, is 20 mM Tris-HCl, pH 8.0, 20% Glycerol, 100 mM KCl, 1 mM DTT, and 0.2 mM EDTA.
SRP2057
LXR β-ligand binding domain (211-461) human
recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Synonym(s):
LXR-b, LXRB, NER, NER-I, RIP15, UNR
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10 μG
$520.00
About This Item
UNSPSC Code:
12352200
NACRES:
NA.26
Recommended Products
biological source
human
recombinant
expressed in E. coli
assay
≥80% (SDS-PAGE)
form
frozen liquid
mol wt
~30.9 kDa
packaging
pkg of 10 μg
concentration
700 μg/mL
color
clear colorless
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... NR1H2(7376)
1 of 4
This Item | SRP2131 | SRP2129 | SRP2137 |
|---|---|---|---|
| biological source human | biological source human | biological source human | biological source human |
| assay ≥80% (SDS-PAGE) | assay ≥80% (SDS-PAGE) | assay ≥70% (SDS-PAGE) | assay ≥70% (SDS-PAGE) |
| recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli |
| concentration 700 μg/mL | concentration 500 μg/mL | concentration 350 μg/mL | concentration 400 μg/mL |
| mol wt ~30.9 kDa | mol wt ~53.3 kDa | mol wt ~76.6 kDa | mol wt ~56.3 kDa |
| form frozen liquid | form frozen liquid | form frozen liquid | form frozen liquid |
Biochem/physiol Actions
Liver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids. There are two subtypes of LXRs, LXR α and LXR β. LXR β is preferentially expressed in liver, small intestine, kidney and spleen. In contrast, LXR α expression is ubiquitous. The genomic structure and the promoter regions of the two LXR genes contain specific regulatory sites, which suggest that LXRs may have physiological roles in the immune system. Like other nuclear receptors, LXRs heterodimerize with retinoid X receptor (RXR) for function. LXRs are activated by naturally occurring oxysterols and regulate the expression of target genes, including ATP binding cassette transporter 1 (ABC1), ATP binding cassette transporter 8 (ABC8) and cholesterol ester transfer protein (CETP). LXR β expressed in livers of LXR α knockout mice does not compensate for the loss of LXR α. In addition, LXR β, but not LXR α, is also able to activate transcription of a reporter gene, which contains a specific direct repeat separated by 1 bp (DR1) element in the promoter, suggesting that LXR β may have different biological functions.
Physical form
Clear and colorless frozen liquid solution
Preparation Note
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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