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SRP2081
Retinoblastoma protein human
recombinant, expressed in insect cells, ≥70% (SDS-PAGE)
Synonym(s):
OSRC, RB, p105-Rb, pRb, pp110, retinoblastoma 1
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| Size/SKU | Availability | Price |
|---|---|---|
5 μg | Usually ships in 2 weeks. | $711.00 |
About This Item
NACRES:
NA.26
UNSPSC Code:
12352202
Form:
frozen liquid
Assay:
≥70% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in insect cells
Mol wt:
~107.5 kDa
biological source
human
recombinant
expressed in insect cells
assay
≥70% (SDS-PAGE)
form
frozen liquid
mol wt
~107.5 kDa
packaging
pkg of 5 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
400 μg/mL
color
clear colorless
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... RB1(5925)
General description
The gene encoding retinoblastoma-associated protein (RB1) is a tumor suppressor gene localized on human chromosome 13q14.2.
Biochem/physiol Actions
pRB, the product of retinoblastoma susceptibility gene RB-1, is one of the best-studied tumor suppressor gene products. At least two other pRB-related proteins, p107 and p130, have been identified and characterized. Mutations in RB-1 gene are often associated with the occurrence of various tumors. The activity of pRB is regulated through phosphorylation in a cell cycle-dependent manner. The hyperphosphorylated RB protein usually associates with the cell nucleus and binds transcription factors of the E2F family. pRB represses transcription of its target genes, such as cdc2, cyclin A, and oncogene c-Myc, c-Fos through the binding with E2F factors and thereby regulating cell proliferation.
Physical form
Clear and colorless frozen liquid solution
Preparation Note
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
1 of 1
This Item | |||
|---|---|---|---|
| biological source human | biological source human | biological source rabbit | biological source rabbit |
| recombinant expressed in insect cells | recombinant expressed in E. coli | recombinant - | recombinant - |
| assay ≥70% (SDS-PAGE) | assay ≥80% (SDS-PAGE) | assay - | assay - |
| concentration 400 μg/mL | concentration >0.02 mg/mL | concentration 4.05 mg/ml | concentration 0.72 mg/ml |
| mol wt ~107.5 kDa | mol wt 43.5 kDa | mol wt 106 | mol wt 106 |
| form frozen liquid | form aqueous solution | form buffered aqueous solution | form buffered aqueous solution |
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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What is the Department of Transportation shipping information for this product?
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What is the composition of the buffer which Product SRP2081, Retinoblastoma protein human, is offered in?
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Product SRP2081, Retinoblastoma protein human, is provided in a buffer consisting of: 20 mM Tris-HCl (pH 8.0), 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA.
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Is there a tag still present or is it cleaved off at the time of purification for Product SRP2081, Retinoblastoma protein human?
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Product SRP2081, Retinoblastoma protein human, has a 6X His-tag attached to its N-terminus.
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