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SRP3038

Sigma-Aldrich

FGF-16 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture

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Synonym(s):
FGFG, Fibroblast Growth Factor-16
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

assay

≥95% (HPLC)
≥95% (SDS-PAGE)

form

lyophilized

potency

≥2x10^6 units/mg

mol wt

23.7 kDa

packaging

pkg of 25 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 EU/μg endotoxin, tested

color

white to off-white

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... FGF16(8823)

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vibrant-m

SRP3038

FGF-16 human

vibrant-m

SRP3043

FGF-basic human

vibrant-m

SRP3039

FGF-23 human

vibrant-m

SRP3100

KGF human

biological source

human

biological source

human

biological source

human

biological source

human

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

mol wt

23.7 kDa

mol wt

17.2 kDa

mol wt

25.5 kDa

mol wt

18.9 kDa

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

General description

Fibroblast growth factor-16 (FGF-16) is a heparin binding growth factor that is a member of the FGF9 subfamily. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. Recombinant human FGF-16 is a 23.7 kDa protein consisting of 207 amino acid residues.

Biochem/physiol Actions

Fibroblast growth factor-16 (FGF-16) signals through FGFR 2c and 3c. FGF-16 plays a role in the development of the central nervous system. This protein has a positive effect on mitosis and cell survival. FGF-16 also has roles in tissue repair, embryonic development, morphogenesis and tumor growth.

Sequence

MAEVGGVFAS LDWDLHGFSS SLGNVPLADS PGFLNERLGQ IEGKLQRGSP TDFAHLKGIL RRRQLYCRTG FHLEIFPNGT VHGTRHDHSR FGILEFISLA VGLISIRGVD SGLYLGMNER GELYGSKKLT RECVFREQFE ENWYNTYAST LYKHSDSERQ YYVALNKDGS PREGYRTKRH QKFTHFLPRP VDPSKLPSMS RDLFHYR

Physical form

Lyophilized from 5 mM sodium phosphate, pH 9.0, containing 0.1 M L-arginine and 0.4 mM DTT.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.5-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Fibroblast growth factor (FGF) signaling in development and skeletal diseases
Chad M
Genes & Development (2014)
High-yield of biologically active recombinant human fibroblast growth factor-16 in E. coli and its mechanism of proliferation in NCL-H460 cells.
Cheng J
Preparative Biochemistry & Biotechnology (2017)
Fibroblast growth factors.
Ornitz, D.M., et al.
Genome Biology, 2, 30051-300512 (2001)

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