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SRP3079

Sigma-Aldrich

IL-16 human

Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

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Synonym(s):
LCF (Lymphocyte Chemoattractant Factor)
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

mol wt

12.4 kDa

packaging

pkg of 10 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 EU/μg endotoxin, tested

color

white to off-white

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... IL16(3603)

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IL-16 human

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IL-16 (121aa) human

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IL-15 human

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SRP3083

IL-1 beta human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

form

lyophilized

form

lyophilized

form

lyophilized

form

lyophilized

mol wt

12.4 kDa

mol wt

12.4 kDa

mol wt

12.9 kDa

mol wt

17.3 kDa

packaging

pkg of 10 μg

packaging

pkg of 10 μg

packaging

pkg of 10 μg

packaging

pkg of 10 μg

General description

IL-16 (interleukin 16), or LCF (lymphocyte chemoattractant factor), was first functionally and biochemically characterized in 1982. IL-16 is produced as a precursor protein (pro-IL16), composed of 631 residues which undergoes cleavage by caspase-3 to produce and secrete a C-terminal biologically active peptide of 121 amino acids. This gene is localized to human chromosome 15q26.3.

Biochem/physiol Actions

IL-16 (interleukin 16) is a pleiotropic proinflammatory cytokine that stimulates chemotactic and immunomodulatory responses of CD4+ (cluster of differentiation) lymphocytes, monocytes, and eosinophils, via signaling through CD4. It prevents HIV (human immunodeficiency virus) replication, and promotes the expression of IL-2R by human T-cells. Study in Chinese population show that polymorphisms in this gene are linked with susceptibility to knee osteoarthritis (OA). IL-16 plays a key role in the release of tumor-related inflammatory cytokines, and the rs4778889 variant in this gene is linked with increased risk of RCC (renal cell cancer) in Chinese population.
Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 12.4kDa protein consisting of 121 amino acid residues.

Sequence

SAASASAASD VSVESTAEAT VCTVTLEKMS AGLGFSLEGG KGSLHGDKPL TINRIFKGAA SEQSETVQPG DEILQLGGTA MQGLTRFEAW NIIKALPDGP VTIVIRRKSL QSKETTAAGD S

Physical form

Lyophilized from 5 mM Sodium Citrate, pH 5.5 + 0.5 mM DTT.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 5% Trehalose) and store in working aliquots at -20°C to -80°C.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Conservation of structure and function between human and murine IL-16.
Keane J et al
Journal of Immunology, 160(12), 5945-5954 (1998)
Assignment of human interleukin 16 (IL16) to chromosome 15q26.3 by radiation hybrid mapping.
Kim HS
Cytogenetics and Cell Genetics, 84(1-2), 93-93 (1999)
IL-16 rs4778889 polymorphism contribution to the development of renal cell cancer in a Chinese population.
Yang SX et al
Genetics and molecular research : GMR, 15(2) (2016)
W W Cruikshank et al.
Journal of immunology (Baltimore, Md. : 1950), 157(12), 5240-5248 (1996-12-15)
We have recently described the cDNA and predicted protein structure of a natural soluble CD4 ligand, IL-16. IL-16 is chemotactic for CD4+ T cells and induces functional IL-2 receptors in CD4+ T cells. The binding of IL-16 to CD4 results
Shi-Xing Luo et al.
PloS one, 10(5), e0123442-e0123442 (2015-05-09)
Interleukin-16 (IL-16), a pleiotropic cytokine, plays a fundamental role in inflammatory diseases. This study investigates the association between IL-16 polymorphisms and the risk of knee osteoarthritis (OA) in a Chinese population. The IL-16 rs11556218, rs4072111, and rs4778889 polymorphisms were determined

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