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SRP3122

Sigma-Aldrich

Neuritin human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Synonym(s):

CPG15, NRN1

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

potency

20.0-30.0 ng/mL ED50

mol wt

9.7 kDa

packaging

pkg of 20 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 EU/μg endotoxin, tested

color

white to off-white

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... NRN1(51299)

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This Item
SRP3126SRP3124SRP3055
recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

biological source

human

biological source

human

biological source

human

biological source

human

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

form

lyophilized

form

lyophilized

form

lyophilized

form

lyophilized

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

NRN1 (neuritin 1) is a highly conserved extracellular GPI (glycosylphosphatidylinositol)-anchored protein that was initially identified in rat hippocampal dentate gyrus in a screening of candidate kainic acid-induced plasticity related genes. This protein is also secreted in a soluble form.[1][2]
Recombinant human Neuritin is a covalently disulfide-linked homodimer, consisting of two 9.8kDa polypeptide monomers, each containing 89 amino acid residues.

Biochem/physiol Actions

NRN1 (neuritin 1) is implicated in synaptic plasticity during brain development, and is an activity-dependent protein. Synaptic plasticity is dependent upon neuronal migration, and a study shows that NRN1 protein facilitates neuronal cell migration, and its levels influence microtubule stability.[1] This protein also promotes dendritic arborization and synapse maturation in the central nervous system (CNS). It facilitates the survival of neural progenitors and differentiated neurons during early embryonic development, and during late development it is responsible for the maturation and formation of synapses by promoting the growth and stabilization of axons and dendrites.[2] Study in human microendothelial cells (HMEC-1) shows that the expression of this protein is hypoxia-induced, and it is a hypoxic perinecrotic marker.[3]
Recombinant human Neuritin is a covalently disulfide-linked homodimer, consisting of two 9.8kDa polypeptide monomers, each containing 89 amino acid residues.

Sequence

MAGKCDAVFK GFSDCLLKLG DSMANYPQGL DDKTNIKTVC TYWEDFHSCT VTALTDCQEG AKDMWDKLRK ESKNLNIQGS LFELCGSGN

Physical form

Lyophilized with no additives.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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