Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta.
Proceedings of the National Academy of Sciences of the USA, 97, 2603-2608 (2000)
Midkine and pleiotrophin in neural development and cancer
Kadomatsu K and Muramatsu T
Cancer Letters, 204, 127-143 (2004)
Thomas F Deuel et al.
Archives of biochemistry and biophysics, 397(2), 162-171 (2002-02-14)
Pleiotrophin (PTN the protein, Ptn the gene) is a 136 amino acid secreted heparin-binding cytokine that signals diverse functions, including lineage-specific differentiation of glial progenitor cells, neurite outgrowth, and angiogenesis. Pleiotrophin gene expression is found in cells in early differentiation...
The International journal of developmental biology, 37(1), 183-188 (1993-03-01)
Using mouse teratocarcinoma system, we found a novel retinoic acid responsive gene. Midkine (MK), the product of the gene is a secreted, heparin-binding protein of molecular weight 14,000. MK gene is intensely expressed in the midgestation period, and in the...
Frank H Lau et al.
PloS one, 7(7), e40423-e40423 (2012-08-01)
Macrodactyly is a rare family of congenital disorders characterized by the diffuse enlargement of 1 or more digits. Multiple tissue types within the affected digits are involved, but skeletal patterning and gross morphological features are preserved. Not all tissues are...