Characterization of a multicomponent receptor for GDNF.
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Transforming growth factor β cooperates with persephin for dopaminergic phenotype induction.
Roussa E, et al.
Stem Cells, 26(7), 1683-1694 (2008)
The RET receptor: function in development and dysfunction in congenital malformation.
Manie S, et al.
Trends in Genetics, 17(10), 580-589 (2001)
Trends in neurosciences, 24(8), 427-429 (2001-07-31)
Glial cell line-derived neurotrophic factor (GDNF) family ligands (GFL) are potent survival factors and regulators for central and peripheral neurons. GFLs bind to specific glycosyl phosphatidylinositol (GPI)-anchored co-receptors (GFRalpha1-alpha4), but signal through a common c-Ret receptor. Both GPI-anchored and soluble...
M Lindahl et al.
Molecular and cellular neurosciences, 15(6), 522-533 (2000-06-22)
Members of the GDNF protein family signal through receptors consisting of a GPI-linked GFRalpha subunit and the transmembrane tyrosine kinase Ret. Here we characterize the mouse Gfra4 and show that it undergoes developmentally regulated alternative splicing in several tissues. The...