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SRP3301

Sigma-Aldrich

MIDKINE mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonym(s):

MK, NEGF-2

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20 μG
$366.00

$366.00

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20 μG
$366.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

$366.00

Usually ships in 2 weeks.

biological source

mouse

recombinant

expressed in E. coli

assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

mol wt

13.4 kDa

packaging

pkg of 20 μg

impurities

<0.1 EU/μg endotoxin, tested

color

white to off-white

UniProt accession no.

P12025

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... MDK(17242)

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This Item
SRP3114SRP3211I5286
MIDKINE mouse recombinant, expressed in E. coli, &#8805;98% (SDS-PAGE), &#8805;98% (HPLC)

SRP3301

MIDKINE mouse

Midkine human recombinant, expressed in E. coli, &#8805;98% (SDS-PAGE), &#8805;98% (HPLC), suitable for cell culture

SRP3114

Midkine human

IL-4 from mouse Animal-component free, recombinant, expressed in E. coli, &#8805;98% (SDS-PAGE), &#8805;98% (HPLC), suitable for cell culture

SRP3211

IL-4 from mouse

IL-3 from mouse Carrier free, recombinant, expressed in E. coli, &#8805;98% (SDS-PAGE), suitable for cell culture

I5286

IL-3 from mouse

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥98% (SDS-PAGE)

biological source

mouse

biological source

human

biological source

mouse

biological source

mouse

form

lyophilized

form

lyophilized

form

lyophilized

form

lyophilized

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

dry ice

impurities

<0.1 EU/μg endotoxin, tested

impurities

<0.1 EU/μg endotoxin, tested

impurities

<0.1 EU/μg endotoxin, tested

impurities

<0.1 EU/μg endotoxin, tested

General description

MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development. MK chemoattracts embryonic neurons, neutrophils and macrophages, and by signaling through the ALK receptor it exerts angiogenic, growth and survival activities during tumorgenesis.

Biochem/physiol Actions

Midkine and its functionally-related protein Pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK). Recombinant murine Midkine is a 13.4 kDa protein containing 123 amino acid residues including five intra-molecular disulfide bonds.

Physical form

Lyophilized from 0.4x PBS, pH 7.4.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0611535

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W Iwasaki et al.
The EMBO journal, 16(23), 6936-6946 (1998-01-31)
Midkine (MK) is a 13 kDa heparin-binding polypeptide which enhances neurite outgrowth, neuronal cell survival and plasminogen activator activity. MK is structurally divided into two domains, and most of the biological activities are located on the C-terminal domain. The solution
Neibla Priego et al.
Nature medicine, 24(7), 1024-1035 (2018-06-13)
The brain microenvironment imposes a particularly intense selective pressure on metastasis-initiating cells, but successful metastases bypass this control through mechanisms that are poorly understood. Reactive astrocytes are key components of this microenvironment that confine brain metastasis without infiltrating the lesion.

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