SRP3330

IL-6 from mouse

Name: IL-6 from mouse
Brand: SIGMA
Price: 243 USD

Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonym(s):

BSF-2, HPGF, IFN-?2, B cell differentiation factor (BCDF)

Slide 1 of 1

Select a Size

10 μG

$243.00

Usually ships in 2 weeks.

Request a Bulk Order

About This Item

NACRES:

NA.32

UNSPSC Code:

12352202

Key Documents

View All Documentation

biological source

mouse

recombinant

expressed in E. coli

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

form

lyophilized

potency

5x10^7 units/mg ED₅₀

mol wt

21.7 kDa

packaging

pkg of 10 μg

impurities

endotoxin, tested

color

white to off-white

UniProt accession no.

P08505

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... IL6(16193)

Related Categories

Animal Component Free Cell Culture Reagents

Cell Culture & Analysis

Cell Culture Supplements & Reagents

Growth Factors and Cytokines

Molecular Biology & Functional Genomics

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item	SRP3212	SRP3211	SRP3213
Sigma-Aldrich SRP3330 IL-6 from mouse	Sigma-Aldrich SRP3212 IL-5 from mouse	Sigma-Aldrich SRP3211 IL-4 from mouse	Sigma-Aldrich SRP3213 IL-9 from mouse
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli
assay ≥98% (HPLC), ≥98% (SDS-PAGE)	assay ≥98% (HPLC), ≥98% (SDS-PAGE)	assay ≥98% (HPLC), ≥98% (SDS-PAGE)	assay ≥98% (HPLC), ≥98% (SDS-PAGE)
biological source mouse	biological source mouse	biological source mouse	biological source mouse
form lyophilized	form lyophilized	form lyophilized	form lyophilized
UniProt accession no. P08505	UniProt accession no. P04401	UniProt accession no. P07750	UniProt accession no. P15247
mol wt 21.7 kDa	mol wt 26.2 kDa	mol wt 13.7 kDa	mol wt 14.3 kDa

General description

Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant murine IL-6 is a 21.7 kDa protein containing 188 amino acid residues.

Application

IL-6 from mouse has been used to study IL-6-mediated inhibition of mouse preadipocyte differentiation.[1]

Biochem/physiol Actions

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R and gp130.[2]

Physical form

Lyophilized from 0.1% TFA

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

0813AFC50

1212AFC50

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

The biology of interleukin-6.

Kishimoto T

Blood, 74, 1-10 (1989)

Polyinosinic-polycytidylic acid inhibits the differentiation of mouse preadipocytes through pattern recognition receptor-mediated secretion of tumor necrosis factor-a.

Yu L

Immunology and Cell Biology, 94, 875-885 (2016)

Effects of Coix Seed Oil on High Fat Diet-Induced Obesity and Dyslipidemia.

Lichun Chen et al.

Foods (Basel, Switzerland), 11(20) (2023-07-11)

Dietary intervention is becoming more popular as a way to improve lipid metabolism and reduce the prevalence of diet-related chronic disorders. We evaluated the effects of several dietary oils on body weight, fat mass, liver weight, and tumor necrosis factor

Polyinosinic-polycytidylic acid inhibits the differentiation of mouse preadipocytes through pattern recognition receptor-mediated secretion of tumor necrosis factor-α.

Lili Yu et al.

Immunology and cell biology, 94(9), 875-885 (2016-10-19)

Viral infections can disturb the functions of adipose tissues and thus result in metabolic diseases. Polyinosinic-polycytidylic acid (poly(I:C)), a synthetic analog of viral double-stranded RNA, induces innate antiviral responses by mimicking viral infection through the activation of pattern recognition receptors

Interleukin-6 and its receptor: a paradigm for cytokines.

T Kishimoto et al.

Science (New York, N.Y.), 258(5082), 593-597 (1992-10-23)

Many cytokines and cytokine receptors involved in the regulation of hematopoiesis, immune responses, and inflammation have been identified and characterized at the molecular level. Several characteristic features of cytokines, such as pleiotropy and redundancy, are now more clearly understood on

View All Related Papers

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service