SRP4145

Sigma-Aldrich

IL-6 from rat

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)

Synonym(s):
B cell differentiation factor (BCDF), HSF, HPGF, BSF-2, MGI-2, IFN-b2
MDL number:
NACRES:
NA.32

biological source

rat

recombinant

expressed in E. coli

assay

≥90% (HPLC)
≥90% (SDS-PAGE)

form

lyophilized

potency

<0.01 ng/mL ED50

mol wt

~21.7 kDa

packaging

pkg of 10 μg

impurities

endotoxin, tested

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

rat ... Il6(24498)

General description

Interleukin- 6 (IL-6) is a potent lymphoid cell growth factor that stimulates the growth and survivability of certain B cells and T cells. It is a pro-inflammatory cytokine. IL-6 originates from mononuclear phagocytes, T and B lymphocytes, vascular endothelial cells and fibroblasts. It has a role in various physiological and pathological processes. IL-6 plays an important role in intracellular signaling pathways. Recombinant rat IL-6 is a 21.7kDa protein containing 187 amino acid residues.

Physical form

Lyophilized without any additives.

Reconstitution

Reconstitute in 10 mM HCl to a concentration of 0.1-1.0 μg/μL. The solution can then be diluted into other aqueous buffers.
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Certificate of Analysis
Certificate of Origin
Targeting interlukin-6 to relieve immunosuppression in tumor microenvironment.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine (2017)
Meta-analysis of the role of IL-6 rs1800795 polymorphism in the susceptibility to prostate cancer: Evidence based on 17 studies.
Liu TZ
Medicine (2017)
Lorena M Amaral et al.
American journal of obstetrics and gynecology, 211(2), 158-158 (2014-02-20)
Preeclampsia is a multisystem disorder recognized as hypertension with proteinuria developing >20 weeks' gestation. Preeclampsia is associated with chronic immune activation characterized by increased T and B lymphocytes, cytokines, and antibodies activating the angiotensin II type I receptor (AT1-AA). Hypertension...
Elin Banke et al.
Metabolism: clinical and experimental, 63(6), 831-840 (2014-04-02)
The bacteria Staphylococcus aureus is part of the normal bacterial flora and produces a repertoire of enterotoxins which can cause food poisoning and toxic shock and might contribute to the pathogenesis of inflammatory diseases. These enterotoxins directly cross-link the T...
Mingming Zhang et al.
PloS one, 9(10), e109146-e109146 (2014-10-03)
It has been shown that Faecalibacterium prausnitzii (F. prausnitzii), one of the dominant intestinal bacterial flora, may protect colonic mucosa against the development of inflammation and subsequent inflammatory bowel disease (IBD), with the underlying mechanisms being unclear. The impacts of...

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