SRP4304

Sigma-Aldrich

NGF-beta from mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

Synonym(s):
Ngf, Nerve Growth Factor β, Ngfb
NACRES:
NA.32
Pricing and availability is not currently available.

biological source

mouse

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE)

form

lyophilized

potency

0.2 ng/mL ED50

mol wt

~13.4 kDa

packaging

pkg of 20 μg

impurities

endotoxin, tested

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Ngf(18049)

General description

Nerve growth factor-β (NGF-β) belongs to the neurotrophin family. The active form of human NGF-β is a homodimer, non-glycosylated chain.

Biochem/physiol Actions

Nerve growth factor-β (NGF-β) is a potent neurotrophic factor that supports the growth and survivability of nerve and/or glial cells. It brings pro-survival effects with the help of receptor tyrosine kinase TrkA. NGF-β is associated with diabetic neuropathy and ischemic heart disease. It is also involved in airway nerve system. NGF-β is also responsible for the pain which is linked with osteoarthritis (OA). It is involved in liver fibrosis, carcinogenesis, angiogenesis and cholangiocyte proliferation.

Physical form

Lyophilized without any additives.

Reconstitution

Reconstitute in water to a concentration of 0.1-1.0 mg/mL containing 1% HSA or BSA. The solution can be diluted into other aqueous buffers and stored at 4°C for 2-7 days or store at –20°C for future use.
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner.
Mnich K
Cell Death & Disease, 5, e1202-e1202 (2014)
Nerve growth factor rescues diabetic mice heart after ischemia/reperfusion injury via up-regulation of the TRPV1 receptor.
Zheng LR
The Journal of Diabetic Complications, 29, 323-328 (2015)
Induction of nerve growth factor expression and release by mechanical and inflammatory stimuli in chondrocytes: possible involvement in osteoarthritis pain.
Arthritis Research & Therapy, 16, R16-R16 (2014)
Up-regulation of nerve growth factor in cholestatic livers and its hepatoprotective role against oxidative stress.
Tsai MS
PLoS ONE, 9, e112113-e112113 (2014)
Expression of nerve growth factor and vascular endothelial growth factor in the inferior alveolar nerve after distraction osteogenesis.
Park BW
International Journal of Oral and Maxillofacial Surgery, 35, 624-630 (2006)

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