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SRP4364

Sigma-Aldrich

VEGF165 from mouse

recombinant, expressed in E. coli

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Synonym(s):
MGC70609, VEGF, VEGF-A, VPF, Vascular endothelial growth factor A, Vascular permeability factor
NACRES:
NA.32

biological source

mouse

recombinant

expressed in E. coli

Assay

≥98%

form

lyophilized

potency

1.0-5 ng/mL

mol wt

~39.0 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Vegfa(22339)

General description

VEGF (vascular endothelial growth factor) is a homodimeric protein secreted by a variety of vascularized tissues. It is expressed embryonically in mice, in the lung mesenchyme and epithelium. It belongs to the group of vascular endothelium-specific growth factors. Mouse VEGF is a 39kDa homodimeric protein consisting of two 165 amino acid polypeptide chains.

Biochem/physiol Actions

VEGF (vascular endothelial growth factor) stimulates endothelial cell growth, angiogenesis, vasculogenesis and capillary permeability. It has a role in the differentiation of mesenchymal stem cells into osteoblasts and adipocytes. Disruption of this gene in mice has been associated with vascular abnormalities.

Physical form

Lyophilized without any additives.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Vascular Endothelial Growth Factor (VEGF) Bioavailability Regulates Angiogenesis and Intestinal Stem and Progenitor Cell Proliferation during Postnatal Small Intestinal Development.
Schlieve CR
PLoS ONE, 11(3), e0151396-e0151396 (2016)
Sequestration of Vascular Endothelial Growth Factor (VEGF) Induces Late Restrictive Lung Disease.
Wieck MM
PLoS ONE, 11(2), e0148323-e0148323 (2016)
Anti-bevacizumab idiotype antibody vaccination is effective in inducing vascular endothelial growth factor-binding response, impairing tumor outgrowth.
Sanches Jde S
Cancer Science, 107(4), 551-555 (2016)
Vascular-specific growth factors and blood vessel formation.
Yancopoulos GD
Nature, 407(6801), 242-248 (2000)
Louisa Mezache et al.
Scientific reports, 10(1), 20463-20463 (2020-11-26)
Atrial fibrillation (AF) is the most common arrhythmia and is associated with inflammation. AF patients have elevated levels of inflammatory cytokines known to promote vascular leak, such as vascular endothelial growth factor A (VEGF). However, the contribution of vascular leak

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