SRP4364

Sigma-Aldrich

VEGF165 from mouse

recombinant, expressed in E. coli

Synonym(s):
MGC70609, VEGF-A, VEGF, Vascular permeability factor, Vascular endothelial growth factor A, VPF
NACRES:
NA.32
Pricing and availability is not currently available.

biological source

mouse

recombinant

expressed in E. coli

assay

≥98%

form

lyophilized

potency

1.0-5 ng/mL

mol wt

~39.0 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Vegfa(22339)

General description

VEGF (vascular endothelial growth factor) is a homodimeric protein secreted by a variety of vascularized tissues. It is expressed embryonically in mice, in the lung mesenchyme and epithelium. It belongs to the group of vascular endothelium-specific growth factors. Mouse VEGF is a 39kDa homodimeric protein consisting of two 165 amino acid polypeptide chains.

Biochem/physiol Actions

VEGF (vascular endothelial growth factor) stimulates endothelial cell growth, angiogenesis, vasculogenesis and capillary permeability. It has a role in the differentiation of mesenchymal stem cells into osteoblasts and adipocytes. Disruption of this gene in mice has been associated with vascular abnormalities.

Physical form

Lyophilized without any additives.

Reconstitution

Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Vascular-specific growth factors and blood vessel formation.
Yancopoulos GD
Nature, 407(6801), 242-248 (2000)
Sequestration of Vascular Endothelial Growth Factor (VEGF) Induces Late Restrictive Lung Disease.
Wieck MM
PLoS ONE, 11(2), e0148323-e0148323 (2016)
Vascular Endothelial Growth Factor (VEGF) Bioavailability Regulates Angiogenesis and Intestinal Stem and Progenitor Cell Proliferation during Postnatal Small Intestinal Development.
Schlieve CR
PLoS ONE, 11(3), e0151396-e0151396 (2016)
Anti-bevacizumab idiotype antibody vaccination is effective in inducing vascular endothelial growth factor-binding response, impairing tumor outgrowth.
Sanches Jde S
Cancer Science, 107(4), 551-555 (2016)
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