SRP4365

Sigma-Aldrich

VEGF165 from rat

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

Synonym(s):
MGC70609, VEGF-A, VEGF, Vascular permeability factor, Vascular endothelial growth factor A, VPF
NACRES:
NA.32
Pricing and availability is not currently available.

biological source

rat

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE)

form

lyophilized

mol wt

~38.4 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

rat ... Vegfa(83785)

General description

VEGF165 (vascular endothelial growth factor 165), also known as VEGF-A, is a homodimeric glycoprotein and is expressed as multiple splice variants. Recombinant rat VEGF is a double, non-glycosylated, polypeptide containing 164 amino acids and having a molecular mass of 38.4kDa.

Application

VEGF165 (vascular endothelial growth factor 165) has been used to study the effects of VEGF on the morphology and survival of neurons and glial cells.

Biochem/physiol Actions

VEGF165 (vascular endothelial growth factor 165) has been shown to have pro-angiogenic properties. It has a role in the proliferation of endothelial cells and neuroprotection.

Physical form

Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5

Reconstitution

Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Different angiogenic pathways characterize superficial and invasive bladder cancer.
O'Brien T
Cancer Research, 55(3), 510-513 (1999)
Sarah A Figley et al.
PloS one, 9(5), e96137-e96137 (2014-05-23)
Following spinal cord injury (SCI) there are drastic changes that occur in the spinal microvasculature, including ischemia, hemorrhage, endothelial cell death and blood-spinal cord barrier disruption. Vascular endothelial growth factor-A (VEGF-A) is a pleiotropic factor recognized for its pro-angiogenic properties;...
Pauline Latzer et al.
CNS neuroscience & therapeutics, 22(6), 440-450 (2016-02-11)
Vascular endothelial growth factor (VEGF) is a hallmark of glioblastoma multiforme (GBM) and plays an important role in brain development and function. Recently, it has been reported that treatment of GBM patients with bevacizumab, an anti-VEGF antibody, may cause a...

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