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SRP4580

Sigma-Aldrich

BMP-14 (GDF-5/CDMP-1) human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

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Synonym(s):
BMP-14/ CDMP-1, Cartilage derived morphogenetic protein-1, GDF-5, bone morphogenetic protein 14
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

potency

0.5-4 μg ED50

mol wt

~27 kDa

packaging

pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... GDF5(8200)

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This Item
SRP4639SRP3326GF168
BMP-13 human recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Sigma-Aldrich

SRP4639

BMP-13 human

BMP-2 human Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Sigma-Aldrich

SRP3326

BMP-2 human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

-

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

>95% (SDS-PAGE and HPLC)

form

lyophilized

form

lyophilized

form

lyophilized

form

-

mol wt

~27 kDa

mol wt

~27 kDa

mol wt

26.0 kDa

mol wt

-

packaging

pkg of 50 μg

packaging

pkg of 50 μg

packaging

pkg of 10 μg

packaging

-

General description

The gene BMP-14 (bone morphogenetic protein 14) is mapped to human chromosome 20q11.22. It belongs to the bone morphogenetic protein family. Recombinant human BMP-14 is a 27kDa homodimeric protein consisting of two 120 amino acid polypeptide chains.

Biochem/physiol Actions

BMP-14 (bone morphogenetic protein 14) is involved in enhancing proliferations of osteoblasts, periosteum cells and connective tissue fibroblasts. It also promotes endochondral bone growth, proper development of limb skeletons and joints, and odontogenesis. It interacts with BMP type II receptor (BMPR-II) and might be involved in bone morphogenesis. Mutations in the BMP-14 gene are associated with brachydactyly type C, intervertebral disc degeneration, acromesomelic dysplasia Grebe type and osteoarthritis.

Physical form

Lyophilized from 10 mM Sodium Citrate, pH 3.5.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute to a concentration of 0.1-1.0 mg/mL in water containing BSA (50 mg BSA per 1 mg of protein). This solution can then be diluted into other aqueous buffers.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Novel homozygous sequence variants in the GDF5 gene underlie acromesomelic dysplasia type-grebe in consanguineous families.
Umair M, et al.
Congenital Anomalies, 57, 45-45 (2017)
Two novel homozygous missense mutations in the GDF5 gene cause brachydactyly type C.
Al-Qattan MM, et al.
American Journal of Medical Genetics, 167, 1621-1621 (2015)
A comprehensive meta-analysis of association between genetic variants of GDF5 and osteoarthritis of the knee, hip and hand.
Zhang R, et al.
Inflammation Research, 64, 405-405 (2015)
Role of growth differentiation factor-5 and bone morphogenetic protein type II receptor in the development of lumbar intervertebral disc degeneration.
Li YF, et al.
International Journal of Clinical and Experimental Pathology, 8, 719-719 (2015)
Xu-wei Luo et al.
Journal of Zhejiang University. Science. B, 17(1), 30-42 (2016-01-08)
To construct a recombinant adenovirus vector-carrying human growth and differentiation factor-5 (GDF-5) gene, investigate the biological effects of adenovirus-mediated GDF-5 (Ad-GDF-5) on extracellular matrix (ECM) expression in human degenerative disc nucleus pulposus (NP) cells, and explore a candidate gene therapy

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