SRP4633

Sigma-Aldrich

VEGF-C human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym(s):
VEGFC, Vascular Endothelial Growth Factor-C
MDL number:
NACRES:
NA.32
Pricing and availability is not currently available.

biological source

human

recombinant

expressed in E. coli

assay

≥90% (SDS-PAGE)

form

lyophilized

mol wt

15-16 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... VEGFC(7424)

General description

The recombinant VEGF-C (vascular endothelial growth factor-C) is a 125 amino acid protein that lacks the N-terminal signal peptide (from T103 to R227 of Gene Bank U58111). Human VEGF-C exhibits about 85% homology with mouse VEGF-C. The VEGFC gene is mapped to human chromosome 4q34.3.

Application

VEGF-C human has been used to determine cell proliferation and survival.

Biochem/physiol Actions

VEGF-C (vascular endothelial growth factor-C) promotes tumorigenesis, by inducing lymphatic metastasis. The production of VEGF-C is stimulated by pro-fibrotic transforming growth factor β. The main function of VEGF-C is to mediate lymphangiogenesis. Overexpression of VEGF-C in keratinocytes of skin causes dermal lymphatic vessel hyperplasia.

Physical form

Lyophilized without additives.

Reconstitution

Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/mL.
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Tumor necrosis factor superfamily 15 promotes lymphatic metastasis via upregulation of vascular endothelial growth factor-C in a mouse model of lung cancer
Qin T, et al.
Cancer Science, 109(8), 2469-2469 (2018)
Connective tissue growth factor regulates fibrosis-associated renal lymphangiogenesis
Kinashi H, et al.
Kidney International, 92(4), 850-863 (2017)
The effect of vascular endothelial growth factor in the progression of bladder cancer and diabetic retinopathy
Aldebasi YH, et al.
International Journal of Clinical and Experimental Medicine, 6(4), 239-239 (2013)
Kazuhide Hayakawa et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(29), 10666-10670 (2011-07-22)
Originally identified as an angiogenic factor, vascular endothelial growth factor (VEGF-A) is now known to play multiple roles in the CNS, including the direct regulation of neuronal and astrocytic functions. Here, we ask whether VEGF-A can also have a novel...
Angiogenesis: From Basic Science to Clinical Applications, 58-58 (2006)

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