SRP4642

Sigma-Aldrich

VEGF-B human

recombinant, expressed in E. coli

Synonym(s):
VEGFB, Vascular Endothelial Growth Factor-B
NACRES:
NA.32
Pricing and availability is not currently available.

biological source

human

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE)

form

lyophilized

potency

0.5-5.0 μg/mL

mol wt

~19.63 kDa

packaging

pkg of 20 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... VEGFB(7423)

General description

Vascular endothelial growth factor B (VEGF-B), a member of the VEGF family, is a potent growth and angiogenic cytokine. VEGF-B is expressed in all tissues except the liver. It forms cell surface-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a "cysteine knot" like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. The gene encoding this protein is localized on human chromosome 11q13 and contains seven exons. Recombinant human VEGF-B is a 38kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.

Biochem/physiol Actions

Vascular endothelial growth factor B (VEGF-B) promotes DNA synthesis in endothelial cells, regulates angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. It has a role in coronary vessel growth and cardiac hypertrophy, which might provide protection to heart against ischemic damage and heart failure. VEGF-B is also involved in neuroprotection. The protein might have a role in metabolic functions since it is highly expressed in tissues with highly active energy metabolism.

Physical form

Lyophilized without any additives.

Reconstitution

Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/mL.
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Roles of Vascular Endothelial Growth Factor in Amyotrophic Lateral Sclerosis
Ana Catarina
BioMed Research International, 947513-947513 (2014)
Vascular endothelial growth factor and angiogenesis.
Hoeben A et al
Pharmacological Reviews, 56(4), 549-580 (2004)
Vascular endothelial growth factor-B in physiology and disease.
Bry M et al
Physiological Reviews, 94(3), 779-794 (2014)

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