VEGF-B human

recombinant, expressed in E. coli

VEGFB, Vascular Endothelial Growth Factor-B
Pricing and availability is not currently available.

biological source



expressed in E. coli


≥98% (SDS-PAGE)




0.5-5.0 μg/mL

mol wt

~19.63 kDa


pkg of 20 μg

storage condition

avoid repeated freeze/thaw cycles


endotoxin, tested

NCBI accession no.

shipped in

wet ice

storage temp.


Gene Information

human ... VEGFB(7423)

General description

Vascular endothelial growth factor B (VEGF-B), a member of the VEGF family, is a potent growth and angiogenic cytokine. VEGF-B is expressed in all tissues except the liver. It forms cell surface-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a "cysteine knot" like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. The gene encoding this protein is localized on human chromosome 11q13 and contains seven exons. Recombinant human VEGF-B is a 38kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.

Biochem/physiol Actions

Vascular endothelial growth factor B (VEGF-B) promotes DNA synthesis in endothelial cells, regulates angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. It has a role in coronary vessel growth and cardiac hypertrophy, which might provide protection to heart against ischemic damage and heart failure. VEGF-B is also involved in neuroprotection. The protein might have a role in metabolic functions since it is highly expressed in tissues with highly active energy metabolism.

Physical form

Lyophilized without any additives.


Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/mL.
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Roles of Vascular Endothelial Growth Factor in Amyotrophic Lateral Sclerosis
Ana Catarina
BioMed Research International, 947513-947513 (2014)
Vascular endothelial growth factor and angiogenesis.
Hoeben A et al
Pharmacological Reviews, 56(4), 549-580 (2004)
Vascular endothelial growth factor-B in physiology and disease.
Bry M et al
Physiological Reviews, 94(3), 779-794 (2014)

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