SRP4651

PTHrP human

Name: PTHrP human
Brand: SIGMA
Price: 395 USD

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonym(s):

HHM, PLP, PTHLH, PTHR, PTHRP

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50 μG

$395.00

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About This Item

UNSPSC Code:

51111800

NACRES:

NA.32

MDL number:

MFCD01635684

Key Documents

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Product Name

PTHrP human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

biological source

human

recombinant

expressed in E. coli

assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

mol wt

~9.8 kDa

packaging

pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

P12272

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... PTHLH(5744)

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Show Differences

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This Item	SRP4639	SRP3319	SRP3015
Sigma-Aldrich SRP4651 PTHrP human	Sigma-Aldrich SRP4639 BMP-13 human	Sigma-Aldrich SRP3319 EGF-L7 human	Sigma-Aldrich SRP3015 Beta NGF human
assay ≥98% (HPLC), ≥98% (SDS-PAGE)	assay ≥95% (SDS-PAGE)	assay ≥98% (HPLC), ≥98% (SDS-PAGE or HPLC)	assay ≥98% (HPLC), ≥98% (SDS-PAGE)
biological source human	biological source human	biological source human	biological source human
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli
form lyophilized	form lyophilized	form lyophilized	form lyophilized
mol wt ~9.8 kDa	mol wt ~27 kDa	mol wt 28.0 kDa	mol wt 13.5 kDa
impurities endotoxin, tested	impurities endotoxin, tested	impurities endotoxin, tested	impurities <0.1 EU/μg endotoxin, tested

Application

The human parathyroid hormone-like related protein (PTHrP) has been used as an osteoarthritis-associated factor regulating hypertrophic differentiation of human chondrocytes.[1] It has also been used in the regulation of the expression of Smpd3 (Sphingomyelin phosphodiesterase 3) in chondrocytes.[2]

Biochem/physiol Actions

The gene PTHrP (parathyroid hormone-like related protein) encodes a protein involved in skeletal development. It binds to the receptor activated by PTH (parathyroid hormone) and functions in smooth muscle relaxation, regulation of cellular proliferation and differentiation. It also regulates endochondral bone development and proliferation of growth plate chondrocytes.[3] It regulates fetal blood calcium and placental calcium transport.[4] It has been associated with malignant hypercalcemia.[5] Mutation in this gene has been associated with brachydactyly type E2 (BDE2).[6]

General description

Parathyroid Hormone-like related Protein (PTHrP) is a member of the Parathyroid hormone family that is expressed in the mammary gland. It is known as a potent inhibitor of chondrocyte maturation. PTHrP is expressed by periarticular perichondrial cells and exerts its biological activity on PP-R expressing cells. During endochondral bone development PTHrP plays a major role in suppressing the onset of hypertrophic differentiation. It is also responsible for most cases of humoral hypercalcemia of malignancy. Recombinant Human PTHrP is a 9.8 kDa protein consisting of 86 amino acid residues.

Recombinant Human PTHrP is a 9.8 kDa protein consisting of 86 amino acid residues.

Physical form

Sterile filtered and lyophilized without additives.

Preparation Note

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors.

Jeroen C H Leijten et al.

Arthritis research & therapy, 15(5), R126-R126 (2013-11-30)

Osteoarthritis is, at least in a subset of patients, associated with hypertrophic differentiation of articular chondrocytes. Recently, we identified the bone morphogenetic protein (BMP) and wingless-type MMTV integration site (WNT) signaling antagonists Gremlin 1 (GREM1), frizzled-related protein (FRZB) and dickkopf

Smpd3 Expression in both Chondrocytes and Osteoblasts Is Required for Normal Endochondral Bone Development.

Li J

Molecular and Cellular Biology, 36, 2282-2299 (2016)

Exome sequencing reveals a novel PTHLH mutation in a Chinese pedigree with brachydactyly type E and short stature.

Wang J

Clinica Chimica Acta; International Journal of Clinical Chemistry, 446:9-44614 (2015)

P38 mitogen-activated protein kinase inhibitor, FR167653, inhibits parathyroid hormone related protein-induced osteoclastogenesis and bone resorption.

Huiren Tao et al.

PloS one, 6(8), e23199-e23199 (2011-09-03)

p38 mitogen-activated protein kinase (MAPK) acts downstream in the signaling pathway that includes receptor activator of NF-κB (RANK), a powerful inducer of osteoclast formation and activation. We investigated the role of p38 MAPK in parathyroid hormone related protein (PTHrP)-induced osteoclastogenesis

The cytology of the gametes and fertilization of Allomyces macrogynus.

Pommerville J and Fuller MS

Archives of Microbiology, 109, 21-30 (1976)

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