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SRP4689

Sigma-Aldrich

Prolactin from rat

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

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Synonym(s):
Luterotropic hormone, Lutetropin, Mammotropin, PRL
NACRES:
NA.32

biological source

rat

recombinant

expressed in E. coli

Assay

≥95% (HPLC)
≥95% (SDS-PAGE)

form

lyophilized

mol wt

~22.5 kDa

packaging

pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

rat ... Prl(24683)

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recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

assay

≥95% (HPLC), ≥95% (SDS-PAGE)

assay

≥95% (HPLC), ≥95% (SDS-PAGE)

assay

≥97% (HPLC), ≥97% (SDS-PAGE)

assay

≥95% (HPLC), ≥95% (SDS-PAGE)

form

lyophilized

form

lyophilized

form

lyophilized

form

lyophilized

mol wt

~22.5 kDa

mol wt

~7.69 kDa

mol wt

~16.3 kDa

mol wt

~12.7 kDa

packaging

pkg of 50 μg

packaging

pkg of 20 μg

packaging

pkg of 50 μg

packaging

pkg of 10 μg

General description

Prl (prolactin) is an anterior pituitary hormone, with a molecular weight of 23kDa. It is processed into several molecular forms such as phosphorylated, glycosylated, and lower molecular weight forms. Cleavage of the native protein results in the production of multiple N-terminal fragments of 14 to 18kDa molecular weights, known as vasoinhibins.
Recombinant mouse Prolactin is a 22.5 kDa globular protein containing 198 amino acid residues.

Biochem/physiol Actions

Prl (prolactin) is processed to lower molecular weight N-terminal fragments, 14-18kDa, called vasoinhibins which have antiangiogenic effects. In endothelial cells, the 16kDa prolactin form exerts antiproliferative and proapoptotic effects which result in cell cycle arrest, caspase and NFκB (nuclear factor) activation, and regulation of Bcl-2 (B-cell lymphoma 2) protein family. In sexually mature female mice, the plasma levels of prolactin remain constant throughout estrous cycle, but show a sudden increase during proestrous cycle due to increase in circulating levels of estrogens. Studies show that Prl activates T cells, B cells, natural killer (NK) cells, macrophages, neutrophils, and dendritic cells, and there is a significant level of hyperprolactinemia incidence in patients with autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Studies in rats show that Prl is involved in T cell homing to mammary glands during early lactation, and that hypoprolactemia during lactation results in modified T cell distribution with increased T cell in circulation and reduced in mammary glands.

Physical form

Sterile filtered and lyophilized from 10 mM Sodium Phosphate, pH 8.0 plus 50 mM NaCl.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 1.0 mg/mL. This solution can then be diluted into other aqueous buffers.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Impaired mammary gland T cell population during early lactation in hypoprolactinemic lactation-deficient rats.
Mackern-Oberti JP et al
Reproduction (Cambridge, England), 146(3), 233-242 (2013)
N-terminal prolactin-derived fragments, vasoinhibins, are proapoptoptic and antiproliferative in the anterior pituitary.
Ferraris J et al
PLoS ONE, 6(7), e21806-e21806 (2011)

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