TSLP human

recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)

Thymic Stromal Lymphopoietin

biological source



expressed in E. coli


≥97% (HPLC)
≥97% (SDS-PAGE)




<0.3 ng/mL ED50

mol wt

~15.0 kDa


pkg of 20 μg

storage condition

avoid repeated freeze/thaw cycles


endotoxin, tested

NCBI accession no.

shipped in

wet ice

storage temp.


Gene Information

human ... TSLP(85480)

General description

Thymic stromal lymphopoietin (TSLP) is a hemopoietic cytokine. It is part of the interleukin-2 (IL-2) cytokine family. It is mainly expressed in the heart, liver and prostate. TSLP is related in its biological activities to interleukin-7 (IL-7) and binds with the heterodimeric receptor complex consisting of interleukin-7 receptor α chain & the TSLP receptor. Recombinant human TSLP produced in Escherichia coli is a single, non-glycosylated polypeptide chain containing 132 amino acids and having a molecular mass of 15kDa.


TSLP human has been used in immunohistochemistry.

Biochem/physiol Actions

Thymic stromal lymphopoietin (TSLP) signals throughout a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the interleukin-7 (IL-7) receptor a chain. TSLP impacts myeloid cells and thus induces the discharge of T cell-attracting chemokines from monocytes and increases the growth of CD11c+ dendritic cells. Similar to IL-7, TSLP enhances phosphorylation of signal transducer and activator of transcription 3 and 5 (STAT3 and STAT5), though uses kinases excluding Janus kinases (JAKs) for its activation. TSLP induces the release of T cell-attracting chemokines such as thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) from monocytes and triggers CD11c+ dendritic cells. TSLP activated dendritic cells primes naive T cells to manufacture pro-allergic cytokines such as interleukin-4, interleukin-5, interleukin-13 and tumor necrosis factor-α (TNF-α), whereas down-regulating interleukin-10 and interferon-γ (IFN-γ) play a role in the initiation of allergic inflammation.

Physical form

Lyophilized from a concentrated solution (1 mg/ml) containing 130 mM NaCl, and 20 mM sodium phosphate, pH 7.4.


Reconstitute in sterile dH2O to a concentration of 0.1 -1 mg/mL and let the lyophilized pellet dissolve completely. This solution can then be diluted into other aqueous buffers.
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity.
Ying S
Journal of Immunology, 174(12), 8183-8190 (2005)
Unusual Timing of CD127 Expression by Mouse Uterine Natural Killer Cells
Jianhong Zhang
Journal of Leukocyte Biology, 91(3), 417-426 (2012)
The biology of thymic stromal lymphopoietin (TSLP).
Ziegler SF
Advances in Pharmacology, 66, 129-155 (2013)
Frederique M Moret et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(5), 1176-1184 (2014-05-02)
To determine the levels of thymic stromal lymphopoietin (TSLP) and the numbers of TSLP receptor (TSLPR)-expressing CD1c+ (blood dendritic cell antigen 1-positive) myeloid dendritic cells (MDCs) in the joints as compared with the peripheral blood (PB) of patients with rheumatoid...
Chun I Yu et al.
Journal of immunology (Baltimore, Md. : 1950), 193(9), 4335-4343 (2014-09-24)
Dendritic cells (DCs) play the central role in the priming of naive T cells and the differentiation of unique effector T cells. In this study, using lung tissues and blood from both humans and humanized mice, we analyzed the response...

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