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SRP5071

Sigma-Aldrich

PTPN1, active, GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

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NACRES:
NA.32

recombinant

expressed in baculovirus infected Sf9 cells

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

2125-2875 nmol/min·mg

mol wt

~71 kDa

NCBI accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PTPN1(5770)

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vibrant-m

SRP5071

PTPN1, active, GST tagged human

assay

≥70% (SDS-PAGE)

assay

-

assay

-

assay

≥70% (SDS-PAGE)

Gene Information

human ... PTPN1(5770)

Gene Information

human ... PTPN1(5770)

Gene Information

human ... PTPN1(5770)

Gene Information

human ... PTPN12(5782)

NCBI accession no.

NM_002827

NCBI accession no.

NM_002827.2

NCBI accession no.

NM_002827.2

NCBI accession no.

NM_002835

form

buffered aqueous glycerol solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous glycerol solution

storage temp.

−70°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−70°C

General description

Protein tyrosine phosphatase nonreceptor, type 1 (PTPN1) is the founding member of the protein tyrosine phosphatase (PTP) family. PTPN1 catalyze the hydrolysis of the phosphate monoesters specifically from tyrosine residues. PTPN1 is known to be involved in signaling pathways that regulate a variety of cellular processes including cell growth and oncogenic transformation. PTPN1 also has been shown to act as a negative regulator of insulin signaling. PTPN1 has also been reported to dephosphorylate epidermal growth factor receptor kinase, which implicated the role of this phosphatase in cell growth control and cell response to interferon stimulation.

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1


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Jennifer L Bento et al.
Diabetes, 53(11), 3007-3012 (2004-10-27)
The PTPN1 gene codes for protein tyrosine phosphatase 1B (PTP1B) (EC 3.1.3.48), which negatively regulates insulin signaling by dephosphorylating the phosphotyrosine residues of the insulin receptor kinase activation segment. PTPN1 is located in 20q13, a genomic region linked to type
Claire Cheyssac et al.
BMC medical genetics, 7, 44-44 (2006-05-09)
The protein tyrosine phosphatase-1B, a negative regulator for insulin and leptin signalling, potentially modulates glucose and energy homeostasis. PTP1B is encoded by the PTPN1 gene located on chromosome 20q13 showing linkage with type 2 diabetes (T2D) in several populations. PTPN1

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