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SRP5074

Sigma-Aldrich

PTPN13 (2169-2485), active, GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

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Synonym(s):
DKFZp686J1497, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE

recombinant

expressed in E. coli

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

2040-2760 nmol/min·mg

mol wt

~61 kDa

NCBI accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PTPN13(5783)

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SRP5072SRP5073SRP5075
PTPN2, active, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

SRP5075

PTPN2, active, GST tagged human

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

specific activity

2040-2760 nmol/min·mg

specific activity

507-687 nmol/min·mg

specific activity

2520-3410 nmol/min·mg

specific activity

6928-9372 nmol/min·mg

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

General description

PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN13 is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. PTPN13 binds to a negative regulatory domain in Fas that inhibits Fas-induced apoptosis.

Physical form

Supplied in 20mM MOPS, pH 7.5, 50mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM PMSF, 30% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1


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J Saras et al.
The Journal of biological chemistry, 269(39), 24082-24089 (1994-09-30)
A novel cytoplasmic protein tyrosine phosphatase (PTP), PTPL1, was identified and cloned using a polymerase chain reaction-based approach. Overlapping cDNA clones encompass an open reading frame of 7398 base pairs, predicting a protein of 2466 amino acid residues with a
J Inazawa et al.
Genomics, 31(2), 240-242 (1996-01-15)
PTPN13 is a protein tyrosine phosphatase that associates with the C-terminal negative regulatory domain in the Fas (APO-1/CD95) receptor. The PTPN13 protein contains six GLGF repeats that have been found in the rat postsynaptic density protein (PSD-95) and the Drosophila

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