SRP5079

PTPRC (592-end), active, GST tagged from mouse

Name: PTPRC (592-end), active, GST tagged from mouse
Brand: SIGMA
Price: 430 USD

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

B220, CD45R, Cd45, Ly-5, Lyt-4, T200, loc

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10 μG

$430.00

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About This Item

UNSPSC Code:

12352200

NACRES:

NA.32

Key Documents

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recombinant

expressed in E. coli

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

8,415-11,385 nmol/min·mg

mol wt

~116 kDa

NCBI accession no.

NM_001111316

shipped in

dry ice

storage temp.

−70°C

Gene Information

mouse ... Ptprc(19264)

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This Item	MABF1471	SRP5333	SRP5078
Sigma-Aldrich SRP5079 PTPRC (592-end), active, GST tagged from mouse	Sigma-Aldrich MABF1471 Anti-CD45 (Mouse), redFluor^® 710, clone 30-F11 Antibody	Sigma-Aldrich SRP5333 PTPRE, active, GST tagged human	Sigma-Aldrich SRP5078 PTPRA (174-802), active, GST tagged human
Gene Information mouse ... Ptprc(19264)	Gene Information mouse ... Ptprc(19264)	Gene Information human ... PTPRE(5791)	Gene Information human ... PTPRA(5786)
assay ≥70% (SDS-PAGE)	assay -	assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)
specific activity 8,415-11,385 nmol/min·mg	specific activity -	specific activity 6880-10320 nmol/min·mg	specific activity 1799-2435 nmol/min·mg
recombinant expressed in E. coli	recombinant -	recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in E. coli
form buffered aqueous glycerol solution	form -	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution
shipped in dry ice	shipped in wet ice	shipped in dry ice	shipped in dry ice

General description

Protein tyrosine phosphatase, receptor type, C (PTPRC) or CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells.[1]

Biochem/physiol Actions

Protein tyrosine phosphatase, receptor type, C (PTPRC) has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling.[2][1]

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

U265-1

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Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes.

E H Fischer et al.

Science (New York, N.Y.), 253(5018), 401-406 (1991-07-26)

Protein tyrosine phosphatases (PTPs) represent a diverse family of enzymes that exist as integral membrane and nonreceptor forms. The PTPs, with specific activities in vitro 10 to 1000 times greater than those of the protein tyrosine kinases would be expected

Mutation in the CD45 Inhibitory Wedge Modulates Integrin Activation and Leukocyte Recruitment during Inflammation

Giulia Germena

Journal of Immunology (2015)

High CD45 surface expression determines relapse risk in children with precursor B-cell and T-cell acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol

Gunnar Cario

Haematologica (2014)

Structural variants of human T200 glycoprotein (leukocyte-common antigen).

S J Ralph et al.

The EMBO journal, 6(5), 1251-1257 (1987-05-01)

Structural variation in the primary structure of human T200 glycoprotein has been detected. Three cDNA variants have been characterized each of which encode T200 molecules that differ in size as a result of sequence differences in their amino-terminal regions. The

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PTPRC (592-end), active, GST tagged from mouse