SRP5093

TLK2 (388-end), active, GST tagged human

Name: TLK2 (388-end), active, GST tagged human
Brand: SIGMA
Price: 587 USD

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

MGC44450, PKU-α

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10 μG

$587.00

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About This Item

NACRES:

NA.32

UNSPSC Code:

12352202

Form:

buffered aqueous glycerol solution

Assay:

≥80% (SDS-PAGE)

Recombinant:

expressed in baculovirus infected Sf9 cells

Mol wt:

~67 kDa

Key Documents

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Product Name

TLK2 (388-end), active, GST tagged human, PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE), buffered aqueous glycerol solution

recombinant

expressed in baculovirus infected Sf9 cells

product line

PRECISIO^® Kinase

assay

≥80% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

67-91 nmol/min·mg

mol wt

~67 kDa

NCBI accession no.

NM_006852

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... TLK2(11011)

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Show Differences

1 of 4

This Item	I6160	SRP5070	SRP5356
Sigma-Aldrich SRP5093 TLK2 (388-end), active, GST tagged human	Sigma-Aldrich I6160 ITK (352-end), active, GST tagged human	Sigma-Aldrich SRP5070 PRKX, active, GST tagged human	Sigma-Aldrich SRP5356 OSR1, GST tagged human
recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in baculovirus infected Sf9 cells
assay ≥80% (SDS-PAGE)	assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)
form buffered aqueous glycerol solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution
mol wt ~67 kDa	mol wt ~53 kDa	mol wt ~73 kDa	mol wt ~86 kDa
specific activity 67-91 nmol/min·mg	specific activity 49-67 nmol/min·mg	specific activity 127-173 nmol/min·mg	specific activity -
Gene Information human ... TLK2(11011)	Gene Information human ... ITK(3702)	Gene Information human ... PRKX(5613)	Gene Information human ... OXSR1(9943)

General description

TLK2 or Tousled-like kinase 2, is a nuclear serine/threonine kinases that is thought to be involved in the regulation of chromatin assembly. In addition, TLK2 is also involved in other cellular processes such as intracellular signaling cascade, protein amino acid phosphorylation, cell cycle, chromatin modification and in response to DNA damage stimulus. TLK2 displays maximal activity during S phase of the cell cycle where it appears to be regulated by cell-cycle-dependent phosphorylation. Inhibition of DNA replication causes a rapid loss of TLK2 activity, indicating that TLK2 function is tightly linked to ongoing DNA replication.

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

H031-1

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Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication.

H H Silljé et al.

The EMBO journal, 18(20), 5691-5702 (1999-10-16)

The Tousled (TSL) gene of the plant Arabidopsis thaliana encodes a serine/threonine kinase that is essential for proper flower development. Here we report the cloning and characterization of two human putative homologues of the Arabidopsis TSL gene, termed TLK1 and

cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal.

A Yamakawa et al.

Gene, 202(1-2), 193-201 (1998-01-14)

We have cloned cDNAs for novel serine/threonine protein kinases (PK), termed PKU-alpha and PKU-beta, by screening a bacteriophage expression library for kinase activity. Sequence analysis of PKU-alpha and PKU-beta genes revealed that their open reading frames (ORF) were 2151 and

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