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SRP6081

Sigma-Aldrich

TXNRD1 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

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Synonym(s):
GRIM-12, MGC9145, TR1, TRXR1, Thioredoxin reductase
CAS Number:
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥95% (SDS-PAGE)

form

liquid

potency

0.48 units/mL

mol wt

55.7 kDa

packaging

pkg of 100 μg

NCBI accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... TXNRD1(7296)

General description

Thioredoxin reductase 1 (TNXRD1), cytoplasmic is an enzyme in humans that is encoded by the TXNRD1 gene. This gene encodes a member of the family of pyridine nucleotide oxidoreductases and is localized on human chromosome 12.

Biochem/physiol Actions

Thioredoxin reductase 1 (TNXRD1) reduces thioredoxins as well as other substrates. It plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses flavin adenine dinucleotide (FAD) as a cofactor. Inhibition of TXNRD1 activity may provide for potential treatments of cancer, acquired immune deficiency syndrome (AIDS), autoimmune diseases as well as bacterial infections and parasitic diseases.

Physical form

0.5 mg/mL solution in PBS (pH 7.4) containing 20% glycerol.

Preparation Note

Centrifuge the vial prior to opening.

Other Notes

MGSSHHHHHH SSGLVPRGSH MYDYDLIIIG GGSGGLAAAK EAAQYGKKVM VLDFVTPTPL GTRWGLGGTC VNVGCIPKKL MHQAALLGQA LQDSRNYGWK VEETVKHDWD RMIEAVQNHI GSLNWGYRVA LREKKVVYEN AYGQFIGPHR IKATNNKGKE KIYSAERFLI ATGERPRYLG IPGDKEYCIS SDDLFSLPYC PGKTLVVGAS YVALECAGFL AGIGLDVTVM VRSILLRGFD QDMANKIGEH MEEHGIKFIR QFVPIKVEQI EAGTPGRLRV VAQSTNSEEI IEGEYNTVML AIGRDACTRK IGLETVGVKI NEKTGKIPVT DEEQTNVPYI YAIGDILEDK VELTPVAIQA GRLLAQRLYA GSTVKCDYEN VPTTVFTPLE YGACGLSEEK AVEKFGEENI EVYHSYFWPL EWTIPSRDNN KCYAKIICNT KDNERVVGFH VLGPNAGEVT QGFAAALKCG LTKKQLDSTI GIHPVCAEVF TTLSVTKRSG ASILQAGC

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Birgitte Zeuner et al.
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Inés Mármol et al.
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Javier Quero et al.
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Fine mapping and identification of a candidate gene SSH1 in disseminated superficial actinic porokeratosis.
Zhang Z
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