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SRP6098

Sigma-Aldrich

GSTP1 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

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Synonym(s):
DFN7, FAEES3, GST3, Glutathione S-transferase P, PI
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥90% (SDS-PAGE)

form

liquid

mol wt

27.6 kDa

packaging

pkg of 100 μg

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... GSTP1(2950)

General description

GSTP1 (glutathione S-transferase P) belongs to the superfamily of glutathione-S-transferases. It is widely expressed and is mainly present in the lung, esophagus and placenta. This gene is mapped to human chromosome 11q13.

Application

GSTP1 human has been used as a standard to measure GST (glutathione S-transferase) activity.

Biochem/physiol Actions

Members of GST (glutathione S-transferase) superfamily are responsible for the metabolism and detoxification various carcinogens, toxins and drugs. GSTP1 can associate with many kinases. Under normal conditions, it associates with c-Jun-N-terminal kinase (JNK) and c-jun. In presence of oxidative or chemical stress, it dissociates from JNK, resulting in its activation. It also associates with peroxiredoxin 1, thereby reactivating it. It interacts with tumor necrosis factor receptor-associated factor 2 (TRAF2). This interaction suppresses TRAF2-associated activation of apoptosis signal-regulating kinase 1, JNK and p38. GSTP1 is also a Cdk5 (cyclin-dependent kinase 5) regulatory protein and determines Cdk5 activity in Alzheimer′s disease brains, as well as in various cancer and neuronal cells. Mutations in the GSTP1 gene might be associated with the severeness of airway dysfunction, treatment outcome of advanced NSCLC (non-small cell lung cancer) in patients and increased risk of OLK (oral leukoplakia).

Physical form

0.5 mg/mL solution in 20 mM Tris-HCl buffer (pH 7.0) containing 1 mM EDTA, 0.1 mM PMSF and 30% glycerol.

Preparation Note

Centrifuge the vial prior to opening.

Other Notes

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMPP YTVVYFPVRG RCAALRMLLA DQGQSWKEEV VTVETWQEGS LKASCLYGQL PKFQDGDLTL YQSNTILRHL GRTLGLYGKD QQEAALVDMV NDGVEDLRCK YISLIYTNYE AGKDDYVKAL PGQLKPFETL LSQNQGGKTF IVGDQISFAD YNLLDLLLIH EVLAPGCLDA FPLLSAYVGR LSARPKLKAF LASPEYVNLP INGNGKQ

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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The Relationship Between Glutathione S-Transferase-P1 and Beta-2 Adrenoreceptor Genotypes with Asthmatic Patients in the Turkish Population.
Kaymak C, et al.
Genetic Testing and Molecular Biomarkers, 20, 522-522 (2016)
Glutathione S-transferase T1, M1 and P1 Genetic Polymorphisms and Susceptibility to Colorectal Cancer in Turkey.
Gorukmez O, et al.
Asian Pacific Journal of Cancer Prevention, 17, 3855-3855 (2016)
Associations Among Glutathione S-Transferase T1, M1, and P1 Polymorphisms and the Risk of Oral Leukoplakia.
He P, et al.
Genetic Testing and Molecular Biomarkers, 20, 312-312 (2016)
Glutathione S-transferase pi polymorphism contributes to the treatment outcomes of advanced non-small cell lung cancer patients in a Chinese population.
Chen JB, et al.
Genetics and molecular research : GMR, 15, doi: 10-doi: 10 (2016)
Tatsunori Okamura et al.
The Journal of biological chemistry, 290(52), 30866-30878 (2015-10-03)
Under normal physiologic conditions, the glutathione S-transferase P1 (GSTP1) protein exists intracellularly as a dimer in reversible equilibrium with its monomeric subunits. In the latter form, GSTP1 binds to the mitogen-activated protein kinase, JNK, and inhibits JNK downstream signaling. In

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