SRP6159

FGF-basic human

recombinant, expressed in human cells, ≥95% (SDS-PAGE)

• Synonym(s): FGF-2, FGF-b, HBGF-2, HBGH-2, Prostatropin
• CAS Number: 62031-54-3
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in human cells
• assay: ≥95% (SDS-PAGE)
• form: lyophilized
• mol wt: 17 kDa (monomer, non-glycosylated)
• packaging: pkg of 10 μg
• technique(s): cell culture | mammalian: suitable
• NCBI accession no.: P09038
• UniProt accession no.: P09038
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... FGF2(2247)

Description

General description

FGF-basic is a member of the fibroblast growth factor (FGF) family. Three alternatively spliced variants encoding different isoforms have been described. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors. The gene encoding this protein is localized on human chromosome 4q28.

Packaging

10 μg

Biochem/physiol Actions

FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. The protein associates with fibroblast growth factor receptors 1, 2 and 3 (FGFR-1, -2, -3).

Physical form

Lyophilized from a PBS solution.

Preparation Note

Centrifuge the vial prior to opening.

Reconstitution

Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable