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SRP6201

Sigma-Aldrich

Amphiregulin human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

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Synonym(s):
AR, AREG, Colorectum cell-derived growth factor (CRDGF)
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥95% (SDS-PAGE)

form

lyophilized powder

mol wt

11.3 kDa

packaging

pkg of 10 μg
pkg of 50 μg

UniProt accession no.

P15514

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... AREG(374)

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This Item
A7080HPA008720171372
Amphiregulin human recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Sigma-Aldrich

SRP6201

Amphiregulin human

Amphiregulin human recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥97% (SDS-PAGE)

Sigma-Aldrich

A7080

Amphiregulin human

Anti-AREG antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Sigma-Aldrich

HPA008720

Anti-AREG antibody produced in rabbit

Sigma-Aldrich

Sigma-Aldrich

171372

Amphiregulin, Human, Recombinant

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

-

recombinant

expressed in E. coli

assay

≥95% (SDS-PAGE)

assay

≥97% (SDS-PAGE)

assay

-

assay

≥97% (SDS-PAGE)

form

lyophilized powder

form

lyophilized powder

form

buffered aqueous glycerol solution

form

liquid

mol wt

11.3 kDa

mol wt

~11 kDa

mol wt

-

mol wt

-

packaging

pkg of 10 μg, pkg of 50 μg

packaging

pkg of 1 mg

packaging

antibody small pack of 25 μL

packaging

-

General description

Amphiregulin is an EGF related growth factor that signals through the EGF/TGF-a receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, amphiregulin′s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. Recombinant human Amphiregulin is a 11.3 kDa glycoprotein consisting of 98 amino acid residues.

Physical form

Sterile filtered through a 0.2 micron filter. Lyophilized from 5 mM Sodium phosphate, pH 7.0.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Michaela Pommer et al.
Cells, 10(2) (2021-02-11)
Oncogene-induced senescence (OIS) is a decisive process to suppress tumor development, but the molecular details of OIS are still under investigation. Using an established OIS model of primary melanocytes transduced with BRAF V600E and compared to control cells, amphiregulin (AREG)

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