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SRP6256

Sigma-Aldrich

VEGF-C human

recombinant, expressed in HEK 293 cells, ≥97% (SDS-PAGE)

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Synonym(s):
Flt4-L, VRP
NACRES:
NA.32

biological source

human

recombinant

expressed in HEK 293 cells

tag

6-His tagged (C-terminus)

assay

≥97% (SDS-PAGE)

form

lyophilized powder

potency

0.15-0.7 μg/mL

mol wt

calculated mol wt 15 kDa
observed mol wt 18-23 kDa (DTT-reduced. Protein migrates due to glycosylation. Thr 103 is the predicted N-terminus .)

packaging

pkg of 10 μg

impurities

<1 EU/μg endotoxin (LAL test)

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... VEGF-C(7424)

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vibrant-m

SRP6256

VEGF-C human

vibrant-m

SRP3183

VEGF-B human

vibrant-m

SRP3182

VEGF human

vibrant-m

SRP6406

VEGFR2/Flk-1/KDR human

assay

≥97% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

recombinant

expressed in HEK 293 cells

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in HEK 293 cells

mol wt

calculated mol wt 15 kDa, observed mol wt 18-23 kDa (DTT-reduced. Protein migrates due to glycosylation. Thr 103 is the predicted N-terminus .)

mol wt

38.0 kDa

mol wt

38.2 kDa

mol wt

calculated mol wt 84.1 kDa, observed mol wt 100-110 kDa by SDS-PAGE (DTT-reduced. Protein migrates due to glycosylation.)

UniProt accession no.

P49767

UniProt accession no.

P49765

UniProt accession no.

P15692

UniProt accession no.

P35968

form

lyophilized powder

form

lyophilized

form

lyophilized

form

lyophilized

General description

Vascular endothelial growth factor C is also known as VEGFC, Flt4-L and VRP; it contains the C-terminal propeptide which has an unusual structure with tandemly repeated cysteine-rich motifs. Upon biosynthesis, VEGFC is secreted as a non-covalent momodimer in an anti-parallel fashion. VEGFC is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis, lymphangiogenesis and endothelial cell growth and survival, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. The structure and function of this protein is similar to those of vascular endothelial growth factor D (VEGF-D). VEGFC may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Overexpression of VEGF-C causes lymphatics to enlarge possibly facilitates metastasis.

Physical form

Lyophilized from 0.22 μm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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